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Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis

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dc.contributor.authorÇELİKEL, ÇİĞDEM
dc.contributor.authorsTahan, Veysel; Eren, Fatih; Avsar, Erol; Yavuz, Dilek; Yuksel, Meral; Emekli, Ebru; Imeryuz, Nese; Celikel, Cigdem; Uzun, Hafize; Haklar, Goncagul; Tozun, Nurdan
dc.date.accessioned2022-03-12T17:32:58Z
dc.date.available2022-03-12T17:32:58Z
dc.date.issued2007
dc.description.abstractRosiglitazone is an insulin-sensitizing agent. We aimed to assess the effects of rosiglitazone on a methionine- and choline-deficient diet (MCDD) model of nonalcoholic steatohepatitis (NASH) in rats. Wistar rats were fed either MCDD or a control diet in the 4-week induction study; they were given saline or 4 mg/kg/day rosiglitazone. After the induction study period, the rats were divided into four groups and fed MCDD or given a control diet for an additional 8 weeks and received saline or rosiglitazone. Serum and tissue samples were obtained. Rosiglitazone improved inflammation in NASH and improved ALT, alkaline phosphatase, and interleukin-6 levels in the induction study and interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha levels in the treatment study. Our preliminary study is the first to show the anti-inflammatory effects of rosiglitazone in NASH. Rosiglitazone's effect on cytokines may be a key mechanism of its anti-inflammatory effect in NASH.
dc.identifier.doi10.1007/s10620-007-9756-x
dc.identifier.issn0163-2116
dc.identifier.pubmed17436085
dc.identifier.urihttps://hdl.handle.net/11424/228739
dc.identifier.wosWOS:000250785400035
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofDIGESTIVE DISEASES AND SCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectrosiglitazone
dc.subjectinsulin resistance
dc.subjectnonalcoholic fatty liver disease
dc.subjectoral glucose tolerance test
dc.subjectreactive oxygen species
dc.subjectcytokine
dc.subjectinterleukin
dc.subjecttumor necrosis factor
dc.subjectGAMMA LIGAND ROSIGLITAZONE
dc.subjectSTELLATE CELL ACTIVATION
dc.subjectCHOLINE-DEFICIENT DIET
dc.subjectINSULIN SENSITIVITY
dc.subjectHEPATIC STEATOSIS
dc.subjectREACTIVE OXYGEN
dc.subjectRECEPTOR-GAMMA
dc.subjectTROGLITAZONE
dc.subjectMETHIONINE
dc.subjectTRIGLYCERIDE
dc.titleRosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis
dc.typearticle
dspace.entity.typePublication
local.avesis.idb75bebb2-7e76-4559-895c-703994cf33f2
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage3472
oaire.citation.issue12
oaire.citation.startPage3465
oaire.citation.titleDIGESTIVE DISEASES AND SCIENCES
oaire.citation.volume52
relation.isAuthorOfPublicationbc2327ed-471c-42da-86dd-cef77979cda2
relation.isAuthorOfPublication.latestForDiscoverybc2327ed-471c-42da-86dd-cef77979cda2

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