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Myrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsOzbeyli, Dilek; Yarimbas, Gizem; Ertas, Busra; Sen, Ali; Sakarcan, Selin; Sener, Goksel
dc.date.accessioned2022-03-12T22:42:55Z
dc.date.available2022-03-12T22:42:55Z
dc.date.issued2020
dc.description.abstractObesity causes cognitive weakening and increases the risk of neurodegenerative diseases. Myrtus connnunis extract (MC) has anti-inflammatory and antioxidant properties. In this study, it is aimed to investigate the effects of Myrtus comniunis on oxidative brain damage caused by a high-fat diet (HFD), using behavioral and biochemical parameters. Twenty- four Wistar albino rats (200-250 g) were divided into three groups. The control group (C) received a standard diet, while HFD groups were received HFD for 16 weeks. MC (100 mg/kg, oral) was given to the HFD + MC group for the last 4 weeks. At the end of the study, the novel object recognition test (NORT) was performed and the hippocampus and blood samples were collected. Acetylcholinesterase (AChE) and Na+/K+- ATPase activities, malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-0HdG) and reduced glutathione (GSH) levels were measured in the hippocampal samples and cholesterol levels were analyzed in sera. Findings have shown that NORT performance of the HFD group was reduced, while administration of MC prevents this reduction and in parallel, increased AChE and decreased Na+/K+-ATPase activities were ameliorated by administration of MC. Increased MDA and 8-OHdG levels observed in the HFD group, were decreased in the MC treated HFD group. Our results point out that MC has ameliorative effects on hippocampal oxidative stress and cognitive impairment in high fat nutrition-induced obesity.
dc.identifier.doi10.35333/jrp.2020.245
dc.identifier.issn2630-6344
dc.identifier.urihttps://hdl.handle.net/11424/236274
dc.identifier.wosWOS:000592829900008
dc.language.isoeng
dc.publisherMARMARA UNIV
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectObesity
dc.subjectoxidative stress
dc.subjectMyrtus communis
dc.subjectacetylcholinesterase
dc.subjectBODY-MASS INDEX
dc.subjectOXIDATIVE STRESS
dc.subjectANTIOXIDANT DEFENSE
dc.subjectOBJECT RECOGNITION
dc.subjectALZHEIMERS-DISEASE
dc.subjectDNA-DAMAGE
dc.subjectOBESITY
dc.subjectINJURY
dc.subjectINFLAMMATION
dc.subjectMECHANISMS
dc.titleMyrtus communis extract ameliorates high-fat diet induced brain damage and cognitive function
dc.typearticle
dspace.entity.typePublication
local.avesis.id27788d05-5d82-40e0-bddc-89a8cac0f75c
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages9
oaire.citation.endPage873
oaire.citation.issue6
oaire.citation.startPage865
oaire.citation.titleJOURNAL OF RESEARCH IN PHARMACY
oaire.citation.volume24
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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