Publication:
VDBP and VDR Mutations May Cause In-Stent Restenosis

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dc.contributor.authorGÜNEY, AHMET İLTER
dc.contributor.authorsKirac D., Yaman A. E. , Gezmis H., Yesilcimen K., Avcilar T., GÜNEY A. İ. , Keles E. C. , KOÇ G., Akkanat R., İSBİR T.
dc.date.accessioned2022-10-31T16:51:17Z
dc.date.available2022-10-31T16:51:17Z
dc.date.issued2022-09-01
dc.description.abstractObjective: In-stent restenosis (ISR) is the narrowing of a stented coronary artery lesion. A considerable number of patients undergoing percutaneous coronary intervention (PCI) are affected by ISR. The predominant mechanism in the development of ISR is an inflammatory response to vessel wall injury during PCI. Vitamin D is reported to have anti-inflammatory properties, so it may also be related with ISR. Therefore, in this study the relationship between vitamin D receptor (VDR), vitamin D binding protein (VDBP) gene variations and ISR were investigated.Methods: Fifty-eight ISR patients who have chest pain, underwent angiography and were found to have restenosis in the previously inserted stent were included in the patient group and thirty-five patients who have chest pain and were not found to have restenosis in their previous stent in coronary angiography were included in the control group. rs7041 and rs4588 variations in VDBP; rs1544410 and rs2228570 variations in VDR were investigated by real-time polymerase chain reaction (RT-PCR).Results were evaluated statistically. Results: The CC genotype of rs2228570 variation of VDR and the CA genotype of rs4588 variation of VDBP were found statistically high in patient group. rs7041 variation was found statistically high in patients who had myocardial infarction history before stent implantation. Additionally, it was demonstrated that vitamin D deficiency (vitamin D level<20 ng/ml) was found statistically high in patient group.Conclusion: It was considered that rs2228570, rs4588 variations and the presence of vitamin D deficiency may play role in the formation of ISR.
dc.identifier.citationKirac D., Yaman A. E. , Gezmis H., Yesilcimen K., Avcilar T., GÜNEY A. İ. , Keles E. C. , KOÇ G., Akkanat R., İSBİR T., "VDBP and VDR Mutations May Cause In-Stent Restenosis", CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.12, sa.3, ss.602-606, 2022
dc.identifier.doi10.33808/clinexphealthsci.953893
dc.identifier.endpage606
dc.identifier.issn2459-1459
dc.identifier.issue3
dc.identifier.startpage602
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/4d626cfa-1250-4043-8684-94d48477494b/file
dc.identifier.urihttps://hdl.handle.net/11424/282685
dc.identifier.volume12
dc.language.isoeng
dc.relation.ispartofCLINICAL AND EXPERIMENTAL HEALTH SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectMedical Ecology and Hydroclimatology
dc.subjectHealth Sciences
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectMEDICINE, RESEARCH & EXPERIMENTAL
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectAraştırma ve Teori
dc.subjectİncelemeler ve Referanslar (tıbbi)
dc.subjectResearch and Theory
dc.subjectReviews and References (medical)
dc.subjectISR
dc.subjectVDR
dc.subjectVDBP
dc.subjectRT-PCR
dc.subjectVITAMIN-D-RECEPTOR
dc.subjectCORONARY-ARTERY-DISEASE
dc.subjectGENE POLYMORPHISMS
dc.subjectULCERATIVE-COLITIS
dc.subjectD DEFICIENCY
dc.subjectASSOCIATION
dc.subjectRISK
dc.subjectPROTEIN
dc.subjectISR
dc.subjectVDR
dc.subjectVDBP
dc.subjectRT-PCR
dc.titleVDBP and VDR Mutations May Cause In-Stent Restenosis
dc.typearticle
dspace.entity.typePublication
local.avesis.id4d626cfa-1250-4043-8684-94d48477494b
local.indexed.atWOS
relation.isAuthorOfPublicationd474fc8a-ae88-487e-b63b-7f506191fb94
relation.isAuthorOfPublication.latestForDiscoveryd474fc8a-ae88-487e-b63b-7f506191fb94

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