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Epithelial barrier dysfunction and microbial dysbiosis: exploring the pathogenesis and therapeutic strategies for Crohn’s disease

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dc.contributor.authorAKKOÇ, TUNÇ
dc.contributor.authorsAKKOÇ T.
dc.date.accessioned2024-09-03T12:06:46Z
dc.date.available2024-09-03T12:06:46Z
dc.date.issued2024-01-01
dc.description.abstractCrohn’s disease (CD), a chronic gastrointestinal inflammatory disease, is becoming more widespread worldwide. Crohn’s disease is caused by gut microbiota changes, genetics, environmental stresses, and immunological responses. Current treatments attempt to achieve long-term remission and avoid complications, delaying disease progression. Immunosuppressive measures and combination medicines should be started early for high-risk patients. These medicines monitor inflammatory indicators and adjust as needed. The epithelial barrier helps defend against physical, chemical, and immunological threats. When tissues’ protective barrier breaks down, the microbiome may reach the layer underneath. Unbalanced microbial populations and inflammation impair healing and adjustment. Inflammatory cells infiltrating sensitive tissues aggravate the damage and inflammation. This approach promotes chronic inflammatory diseases. The epithelial barrier hypothesis states that hereditary and environmental variables cause epithelial tissue inflammation. This review focuses on how epithelial barrier break-down and microbial dysbiosis cause Crohn’s disease and current advances in understanding the epithelial barrier, immune system, and microbiome. Additionally, investigate treatments that restore barrier integrity and promote microbial balance. Overall, it stresses the role of epithelial barrier failure and microbial dysbiosis in Crohn’s disease development and discusses current advances in understanding the barrier, immunological responses, and microbiota.
dc.identifier.citationAKKOÇ T., "Epithelial barrier dysfunction and microbial dysbiosis: exploring the pathogenesis and therapeutic strategies for Crohn’s disease", Tissue Barriers, 2024
dc.identifier.doi10.1080/21688370.2024.2390705
dc.identifier.issn2168-8362
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85202040465&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/297608
dc.language.isoeng
dc.relation.ispartofTissue Barriers
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectHistoloji-Embriyoloji
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectHistology and Embryology
dc.subjectSurgery Medicine Sciences
dc.subjectPathology
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectBiochemistry
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (Life)
dc.subjectBiyoloji Ve Biyokimya
dc.subjectMoleküler Biyoloji Ve Genetik
dc.subjectHücre Biyolojisi
dc.subjectBiyokimya Ve Moleküler Biyoloji
dc.subjectLife Sciences (Life)
dc.subjectBiology & Biochemistry
dc.subjectMolecular Biology & Genetics
dc.subjectCell Biology
dc.subjectBiochemistry & Molecular Biology
dc.subjectHistoloji
dc.subjectHistology
dc.subjectCrohn’s disease pathogenesis
dc.subjectepithelial barrier dysfunction
dc.subjectimmune responses
dc.subjectmicrobial dysbiosis
dc.subjecttherapeutic strategies
dc.titleEpithelial barrier dysfunction and microbial dysbiosis: exploring the pathogenesis and therapeutic strategies for Crohn’s disease
dc.typearticle
dspace.entity.typePublication
local.avesis.idfb45fb1b-a098-4e7a-9aa6-1057c4504427
local.indexed.atPUBMED
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscoverydde3c531-d82d-492a-96eb-d6724483eaa1

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