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Serum prolidase and IGF-1 as non-invasive markers of hepatic fibrosis during four different periods after bile-duct ligation in rats

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dc.contributor.authorÇELİKEL, ÇİĞDEM
dc.contributor.authorsTarcin, Orhan; Gedik, Nursal; Karakoyun, Berna; Tahan, Veysel; Sood, Gagan; Celikel, Cigdem; Tozun, Nurdan
dc.date.accessioned2022-03-12T17:35:46Z
dc.date.available2022-03-12T17:35:46Z
dc.date.issued2008
dc.description.abstractAim Our aim was to study the correlation of serum prolidase and insulin like growth factor-1 to liver collagen and assess their utility as markers of fibrosis during four different periods of hepatic injury and fibrosis after bile-duct ligation in rats. Methods Forty-eight Wistar albino rats were included in the study and divided into six groups. Seven rats served as the control group (Control), while seven rats had a sham operation (Sham group). Thirty-four rats underwent bile-duct ligation. Bile-duct ligated (BDL) animals were sacrificed at the end of the first week (Group 1; n = 8), second week (Group 2; n = 8), third week (Group 3; n = 9), or fourth week (Group 4; n = 9) after BDL. Liver collagen, liver prolidase, and serum prolidase and IGF-1, were determined. Results There was a positive correlation between liver collagen and serum prolidase (r(s): 0.843, P < 0.001) levels and a negative correlation among liver collagen and serum IGF-1 levels (r(s): -0.667, P < 0.001). The peak levels of liver collagen and serum prolidase were reached in the third week while the lowest levels of IGF-1 were found at the end of the third week. Conclusion Serum prolidase and IGF-1 either independently or in combination correlate with liver collagen content in hepatic fibrosis.
dc.identifier.doi10.1007/s10620-007-0073-1
dc.identifier.issn0163-2116
dc.identifier.pubmed17999185
dc.identifier.urihttps://hdl.handle.net/11424/229203
dc.identifier.wosWOS:000256314500030
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofDIGESTIVE DISEASES AND SCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectprolidase
dc.subjectIGF-1
dc.subjectcollagen
dc.subjecthepatic fibrosis
dc.subjectserum marker
dc.subjectbile-duct ligation
dc.subjectGROWTH-FACTOR-I
dc.subjectLIVER FIBROSIS
dc.subjectPLASMA PROLIDASE
dc.subjectBINDING-PROTEIN
dc.subjectCIRRHOSIS
dc.subjectCOLLAGEN
dc.subjectINDEX
dc.subjectHORMONE
dc.subjectDISEASE
dc.subjectPROGRESSION
dc.titleSerum prolidase and IGF-1 as non-invasive markers of hepatic fibrosis during four different periods after bile-duct ligation in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.ide1b4f529-edd0-4204-93d9-924dd1a13833
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage1945
oaire.citation.issue7
oaire.citation.startPage1938
oaire.citation.titleDIGESTIVE DISEASES AND SCIENCES
oaire.citation.volume53
relation.isAuthorOfPublicationbc2327ed-471c-42da-86dd-cef77979cda2
relation.isAuthorOfPublication.latestForDiscoverybc2327ed-471c-42da-86dd-cef77979cda2

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