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Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma

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dc.contributor.authorDANE, FAYSAL
dc.contributor.authorsTuran, Nedim; Benekli, Mustafa; Unal, Olcun Umit; Unek, Ilkay Tugba; Tastekin, Didem; Dane, Faysal; Algin, Efnan; Ulger, Sukran; Eren, Tulay; Topcu, Turkan Ozturk; Turkmen, Esma; Babacan, Nalan Akgul; Tufan, Gulnihal; Urakci, Zuhat; Ustaalioglu, Basak Oven; Uysal, Ozlem Sonmez; Ercelep, Ozlem Balvan; Taskoylu, Burcu Yapar; Aksoy, Asude; Canhoroz, Mustafa; Demirci, Umut; Dogan, Erkan; Berk, Veli; Balakan, Ozan; Ekinci, Ahmet Siyar; Uysal, Mukremin; Petekkaya, Ibrahim; Ozturk, Selcuk Cemil; Tonyali, Onder; Cetin, Bulent; Aldemir, Mehmet Naci; Helvaci, Kaan; Ozdemir, Nuriye; Oztop, Ilhan; Coskun, Ugur; Uner, Aytug; Ozet, Ahmet; Buyukberber, Suleyman
dc.date.accessioned2022-03-12T20:27:01Z
dc.date.available2022-03-12T20:27:01Z
dc.date.issued2015
dc.description.abstractBackground: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma (PAC). Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013. Results: Of 563 patients, 472 received adjuvant chemotherapy (CT) alone, chemoradiotherapy (CRT) alone, and chemoradiotherapy plus chemotherapy (CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival (RFS) and overall survival (OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant difference between groups when patients with node-negative disease or patients with or without positive surgical margins were considered. Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.
dc.identifier.doi10.3978/j.issn.1000-9604.2015.08.03
dc.identifier.eissn1993-0631
dc.identifier.issn1000-9604
dc.identifier.pubmed26361410
dc.identifier.urihttps://hdl.handle.net/11424/233609
dc.identifier.wosWOS:000360940900010
dc.language.isoeng
dc.publisherAME PUBL CO
dc.relation.ispartofCHINESE JOURNAL OF CANCER RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPancreatic adenocarcinoma
dc.subjectadjuvant chemotherapy (adjuvant CT)
dc.subjectadjuvant radiotherapy
dc.subjectSINGLE-INSTITUTION EXPERIENCE
dc.subjectRANDOMIZED CONTROLLED-TRIAL
dc.subjectSEER REGISTRY DATA
dc.subjectPHASE-III
dc.subjectRADIATION-THERAPY
dc.subjectFOLINIC ACID
dc.subjectCANCER
dc.subjectCHEMOTHERAPY
dc.subjectRADIOTHERAPY
dc.subjectGEMCITABINE
dc.titleImpact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma
dc.typearticle
dspace.entity.typePublication
local.avesis.id2a575008-9101-452c-b31d-7387ccfab684
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage416
oaire.citation.issue4
oaire.citation.startPage408
oaire.citation.titleCHINESE JOURNAL OF CANCER RESEARCH
oaire.citation.volume27
relation.isAuthorOfPublication059ce50a-8d16-4fc6-a86c-85c9baa19a5c
relation.isAuthorOfPublication.latestForDiscovery059ce50a-8d16-4fc6-a86c-85c9baa19a5c

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