Publication:
Male infertility in Sertoli cell-only syndrome: An investigation of autosomal gene defects

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dc.contributor.authorGÜNEY, AHMET İLTER
dc.contributor.authorsKoc, Gulsah; Ozdemir, Abdullah A.; Girgin, Gozde; Akbal, Cem; Kirac, Deniz; Avcilar, Tuba; Guney, Ahmet I.
dc.date.accessioned2022-03-14T09:18:09Z
dc.date.available2022-03-14T09:18:09Z
dc.date.issued2019-02
dc.description.abstractObjectives To detect autosomal genetic defects and to determine candidate genes in Sertoli cell-only syndrome infertile men. Methods Single-nucleotide polymorphism + comparative genomic hybridization microarray technology was carried out on 39 Sertoli cell-only syndrome infertile patients in the present study. Array comparative genomic hybridization compares the patient's genome against a reference genome, and identifies uncover deletions, amplifications and loss of heterozygosity. Results A link between defective spermatogenesis genes and infertility was examined, and amplifications and deletions in several genes were detected, including homeobox gene; synaptonemal complex element protein 1; collagen, type I, alpha 1; imprinted maternally expressed transcript; and potassium voltage-gated channel subfamily Q member 1. Conclusions The present data suggest that several genes can play an important role in spermatogenesis and progression of Sertoli cell-only syndrome.
dc.identifier.doi10.1111/iju.13863
dc.identifier.eissn1442-2042
dc.identifier.issn0919-8172
dc.identifier.pubmed30478911
dc.identifier.urihttps://hdl.handle.net/11424/242937
dc.identifier.wosWOS:000457782400024
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofINTERNATIONAL JOURNAL OF UROLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectarray comparative genomic hybridization
dc.subjectinfertility
dc.subjectSertoli cell-only syndrome
dc.subjectDNA METHYLATION
dc.subjectEXPRESSION
dc.subjectPATTERNS
dc.subjectMEIOSIS
dc.titleMale infertility in Sertoli cell-only syndrome: An investigation of autosomal gene defects
dc.typearticle
dspace.entity.typePublication
local.avesis.id4d298467-064a-46e1-b9bd-6667ecf80e19
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ2
oaire.citation.endPage298
oaire.citation.issue2
oaire.citation.startPage292
oaire.citation.titleINTERNATIONAL JOURNAL OF UROLOGY
oaire.citation.volume26
relation.isAuthorOfPublicationd474fc8a-ae88-487e-b63b-7f506191fb94
relation.isAuthorOfPublication.latestForDiscoveryd474fc8a-ae88-487e-b63b-7f506191fb94

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