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Synthesis and evaluation of the anticonvulsant activities of some 5-(4-substitutedbenzylidene)-6-methyl-4,5-dihydropyridazine-3(2H)-ones

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dc.contributor.authorGÖREN, MEHMET ZAFER
dc.contributor.authorsÜNSAL TAN O., Balkan A., Aypak C., TERZİOĞLU BEBİTOĞLU B., GÖREN M. Z.
dc.date.accessioned2023-05-22T08:07:08Z
dc.date.available2023-05-22T08:07:08Z
dc.date.issued2004-12-01
dc.description.abstractIn this study, starting from 3-benzylidene-4-oxopentanoic add derivatives (1a-e), having 5-benzylidene-6-methyl-4,5-dihydropyridazine-3(2H)-one (2a-e) structure and their ester (3a-e), hydrazide (4a-e) and acetic acid (5a-e) derivatives were synthesized. The physical properties and UV absorptions of the five starting compounds (1a-e) and twenty target compounds (2a-5e) were determined. Their chemical structures were achieved by IR and 1H-NMR spectral data. Additionally, elemental analysis data of the new compounds (1b, 2b, 3b, 4b, 5b, 3c, 4c, 5c, 2e, 3e, 4e and 5e) were done to identify the structures. Anticonvulsant activities of the target compounds (2a-5e) were screened by pentylenetetrazole seizure model. It was observed that compound 2a showed an anticonvulsant effect similar to ethosuximide concerning the seizure grade.
dc.identifier.citationÜNSAL TAN O., Balkan A., Aypak C., TERZİOĞLU BEBİTOĞLU B., GÖREN M. Z., "Synthesis and evaluation of the anticonvulsant activities of some 5-(4-substitutedbenzylidene)-6-methyl-4,5-dihydropyridazine-3(2H)-ones", Fabad Journal of Pharmaceutical Sciences, cilt.29, sa.4, ss.185-194, 2004
dc.identifier.endpage194
dc.identifier.issn1300-4182
dc.identifier.issue4
dc.identifier.startpage185
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33744478180&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/289472
dc.identifier.volume29
dc.relation.ispartofFabad Journal of Pharmaceutical Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTROPİKAL TIP
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectTROPICAL MEDICINE
dc.subjectFarmasötik bilim
dc.subjectYaşam Bilimleri
dc.subjectPharmaceutical Science
dc.subjectLife Sciences
dc.subject4,5-dihydropyridazine-3(2H)-one
dc.subject6-oxo-5,6-dihydropyridazinylacetate
dc.subject6-oxo-5,6-dihydropyridazinylacetic acid
dc.subject6-oxo-5,6-dihydropyridazinylacetohydrazide
dc.subjectAnticonvulsant activity
dc.titleSynthesis and evaluation of the anticonvulsant activities of some 5-(4-substitutedbenzylidene)-6-methyl-4,5-dihydropyridazine-3(2H)-ones
dc.typearticle
dspace.entity.typePublication
local.avesis.idfafd533f-01d2-4e00-b066-593259fe427c
local.indexed.atSCOPUS
relation.isAuthorOfPublicationf91c1cf5-3919-48eb-a772-35abafdc304e
relation.isAuthorOfPublication.latestForDiscoveryf91c1cf5-3919-48eb-a772-35abafdc304e

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