Publication:
The effects of Urtica dioica L. ethanolic extract against urinary calculi in rats

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dc.contributor.authorDOĞAN, AHMET
dc.contributor.authorsKeles, Rumeysa; Sen, Ali; Ertas, Busra; Kayali, Damla; Eker, Pinar; Sener, Tarik Emre; Dogan, Ahmet; Cetinel, Sule; Sener, Goksel
dc.date.accessioned2022-03-14T10:13:26Z
dc.date.available2022-03-14T10:13:26Z
dc.date.issued2020-03-12
dc.description.abstractNephrolithiasis is common urological problem and stone formation has multiple underlying pathogenetic factors. We investigated the possible preventive and therapeutic effect of Urtica dioica ethanol extract (UD) on ethylene glycol-induced nephrolithiasis model in rats. Sprague-Daw ley rats were divided into lour groups (n = 10). The control group was given normal drinking water for 8 weeks and was administered vehicle by gastric gavage. Stone formation was induced by adding 0.75% ethylene glycol (EG) to their drinking water. UD (700 mg/kg) was given orally lor 8 weeks to the preventive group and I or last 4 weeks to the treatment respectively. At the end of the experiment, urine, blood samples and kidney tissues were obtained. In 24-hour urine samples, calcium and citrate levels were decreased and oxalate levels were increased in EG whereas LID treatment groups reversed these parameters back to control levels. In addition, serum levels of creatinine and urea were increased in EG while LID significantly reduced these parameters. Malondialdehyde, 8-hydroxydeoxyguanosine and tumor necrosis alpha levels, and caspase- 3 and N-acetyl-beta-glucosaminidase activities were elevated in EG group and showed a decrease in LID treated groups. Glutathione level was decreased in EG group, whereas it was increased in UD preventive group. Histological examination showed an improvement in UD treated groups. Our results suggest that UD is effective both in prevention and treatment for kidney stones. The mechanism underlying this effect may be the antioxidant effect of UD and the effect on the concentration of stone-forming components in the urine.
dc.identifier.doi10.35333/jrp.2020.137
dc.identifier.issn2630-6344
dc.identifier.urihttps://hdl.handle.net/11424/244222
dc.identifier.wosWOS:000520855700004
dc.language.isoeng
dc.publisherMARMARA UNIV
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUrtica dioica
dc.subjectkidney stone
dc.subjectcalcium oxalate
dc.subjecturolithiasis
dc.subjectantioxidant
dc.subjectGLYCOL-INDUCED UROLITHIASIS
dc.subjectANTIOXIDANT
dc.subjectKIDNEY
dc.subjectNEPHROLITHIASIS
dc.subjectNEPHROTOXICITY
dc.subjectINFLAMMATION
dc.subjectINJURY
dc.titleThe effects of Urtica dioica L. ethanolic extract against urinary calculi in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id3e597d60-7999-42bf-9f1d-9f359f1e8f4f
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages13
oaire.citation.endPage217
oaire.citation.issue2
oaire.citation.startPage205
oaire.citation.titleJOURNAL OF RESEARCH IN PHARMACY
oaire.citation.volume24
relation.isAuthorOfPublication34e928c8-270a-41b3-8311-23fba8b897ed
relation.isAuthorOfPublication.latestForDiscovery34e928c8-270a-41b3-8311-23fba8b897ed

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