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Resveratrol treatment may preserve the erectile function after radiotherapy by restoring antioxidant defence mechanisms, SIRT1 and NOS protein expressions

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dc.contributor.authorATASOY, BESTE MELEK
dc.contributor.authorsSener, Tarik Emre; Tavukcu, Hasan Huseyin; Atasoy, Beste Melek; Cevik, Ozge; Kaya, Ozlem Tugce; Cetinel, Sule; Degerli, Ayse Dagli; Tinay, Ilker; Simsek, Ferruh; Akbal, Cem; Buttice, Salvatore; Sener, Goksel
dc.date.accessioned2022-03-12T22:27:34Z
dc.date.available2022-03-12T22:27:34Z
dc.date.issued2018
dc.description.abstractRadiotherapy (RT) for prostate cancer (PC) can cause erectile dysfunction (ED) by damaging neurovascular structures with oxidative stress. In this study, we evaluated the effects of resveratrol, an antioxidant, on post-RT ED. Fifty rats in five groups were evaluated; control (C), prostate-confined radiotherapy with short- and long-term vehicle or resveratrol treatment. Cavernosal tissues were obtained to analyze glutathione (GSH), nitric oxide (NO), cyclic guanosine monophosphate (cGMP), 8-hydroxy-2'-deoxy-guanosine (8-OHdG) levels and superoxide dismutase (SOD), caspase-3 activities, sirtuin-1, Foxo-3, nNOS, and eNOS protein expressions. Intracavernosal pressures (ICP) were measured for the long-term treatment group. In the RT long-term vehicle treatment group, tissue GSH, NO, cGMP, and SOD activity were decreased while 8-OHdg levels and caspase-3 activities were increased. Radiotherapy caused a decrease in sirtuin-1, nNOS, and eNOS protein expressions. These parameters were reversed by resveratrol treatment. Foxo-3 protein expressions were unaltered in the RT + short-term vehicle treatment group and started to increase as a defense mechanism in the RT long-term vehicle group; however, resveratrol treatment caused a significant increase in Foxo-3 expressions. Resveratrol preserved the metabolic pathways involved in erectile function and provided functional protection. Resveratrol can be used as a supplementary agent in patients undergoing radiotherapy to preserve erectile function.
dc.identifier.doi10.1038/s41443-018-0042-6
dc.identifier.eissn1476-5489
dc.identifier.issn0955-9930
dc.identifier.pubmed29973698
dc.identifier.urihttps://hdl.handle.net/11424/235217
dc.identifier.wosWOS:000443568400006
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofINTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRADIATION-THERAPY
dc.subjectPROSTATE-CANCER
dc.subjectRAT MODEL
dc.subjectOXIDATIVE STRESS
dc.subjectDIABETIC-RATS
dc.subjectDYSFUNCTION
dc.subjectPREVENTION
dc.subjectSILDENAFIL
dc.subjectCARCINOMA
dc.subjectTADALAFIL
dc.titleResveratrol treatment may preserve the erectile function after radiotherapy by restoring antioxidant defence mechanisms, SIRT1 and NOS protein expressions
dc.typearticle
dspace.entity.typePublication
local.avesis.id847adac5-05d9-4b6d-9524-4030d97ffd02
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
local.journal.quartileQ4
oaire.citation.endPage188
oaire.citation.issue4
oaire.citation.startPage179
oaire.citation.titleINTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
oaire.citation.volume30
relation.isAuthorOfPublication22ce1b48-93da-4e88-a61e-be24b5e6122a
relation.isAuthorOfPublication.latestForDiscovery22ce1b48-93da-4e88-a61e-be24b5e6122a

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