Publication:
Carbon nanofiber—sodium alginate composite aerogels loaded with vitamin D: The cytotoxic and apoptotic effects on colon cancer cells

Simple item page
dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorsBingol Ozakpinar Ö., Dastan H., Gurboga M., Sayin F. S., Ozsavci D., Caliskan Salihi E.
dc.date.accessioned2023-07-13T08:39:14Z
dc.date.available2023-07-13T08:39:14Z
dc.date.issued2023-07-01
dc.description.abstractColorectal cancer (CRC) is the fourth most commonly diagnosed cancer and the third leading cause of cancer-related deaths worldwide. A substantial body of literature supports the crucial role of vitamin D (VD) in the etiology, progression, prognosis, and treatment of cancer. Recent clinical studies have found an inverse correlation between CRC incidence and serum VD levels. However, the low water solubility of VD and its anticarcinogenic activity at supraphysiological plasma levels, which causes hypercalcemia, required carrier systems. Carbon-based nanomaterials are excellent eco-friendly candidates, with exceptional chemical resistance, efficient mechanical properties, and negligible weight. Furthermore, composite aerogels manufactured from these nanomaterials have gained interest due to their extensive surface areas and porous structures, which make them suitable for delivering drugs. Our research aimed to study the development of composite aerogels loaded with VD by utilizing carbon nanofibers (CNFs) in an aerogel matrix provided to colon cancer cells. For this purpose, Aero1 as a drug delivery system was first prepared and characterized using XRD, FTIR, and SEM methods. Biochemical methods were employed to evaluate the antiproliferative, apoptotic, and anti-migratory effects on colon cancer cells. FTIR and XRD measurements confirmed the production of aerogels. SEM analysis revealed that aerogels have a non-uniform surface. The findings showed that aerogels can effectively deliver VD to the colon cancer cells, while also inhibiting cancer cell proliferation and migration. This research suggests that the Aero1 drug delivery system could be a valuable tool in the fight against colon cancer and other health issues.
dc.identifier.citationBingol Ozakpinar Ö., Dastan H., Gurboga M., Sayin F. S., Ozsavci D., Caliskan Salihi E., "Carbon Nanofiber—Sodium Alginate Composite Aerogels Loaded with Vitamin D: The Cytotoxic and Apoptotic Effects on Colon Cancer Cells", GELS, cilt.9, sa.7, ss.1-17, 2023
dc.identifier.doi10.3390/gels9070561
dc.identifier.endpage17
dc.identifier.issn2310-2861
dc.identifier.issue7
dc.identifier.startpage1
dc.identifier.urihttps://www.mdpi.com/2310-2861/9/7/561/pdf
dc.identifier.urihttps://hdl.handle.net/11424/291229
dc.identifier.volume9
dc.language.isoeng
dc.relation.ispartofGELS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectBiyokimya
dc.subjectSağlık Bilimleri
dc.subjectBasic Pharmaceutics Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectBiochemistry
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectFarmakoloji
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectİlaç Rehberleri
dc.subjectYaşam Bilimleri
dc.subjectPharmacy
dc.subjectPharmacology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectDrug Guides
dc.subjectLife Sciences
dc.subjectvitamin D
dc.subjectdrug delivery system
dc.subjectcarbon nanofiber
dc.subjectaerogel
dc.subjectcolon cancer cells
dc.subjectapoptosis
dc.titleCarbon nanofiber—sodium alginate composite aerogels loaded with vitamin D: The cytotoxic and apoptotic effects on colon cancer cells
dc.typearticle
dspace.entity.typePublication
local.avesis.id741bd5b4-ce4e-4941-82bf-5f687d6f3a3a
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
8.pdf
Size:
5.41 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs