Publication:
Effect of electric stimulus on human adipose-derived mesenchymal stem cells cultured in 3D-printed scaffolds

Simple item page
dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsBedir, Tuba; Ulag, Songul; Aydogan, Kivanc; Sahin, Ali; Yilmaz, Betul Karademir; Guvenc, Yahya; Bozlar, Michael; Ustundag, Cem Bulent; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:43:48Z
dc.date.available2022-03-12T22:43:48Z
dc.date.issued2021
dc.description.abstractElectrical stimulation has shown great potential for nerve regeneration processes. This makes it attractive to use electrically active materials in the neural scaffold. In this paper, bismuth ferrite (BFO) nanoparticles were synthesized via co-precipitation method and incorporated to 10 wt% polylactic acid (PLA) in chloroform to obtain 3D-printed PLA/BFO biocomposites. The crystallinity of BFO nanoparticles was confirmed by XRD, and we studied its chemical structure with FTIR, as well as the mechanical properties of the 3D-printed composites. in vitro studies show that 3D-printed scaffolds have no cytotoxicity and support the proliferation of human adipose-derived mesenchymal stem cells (hADMSCs). Furthermore, 3D scaffolds embedded with BFO shows the highest cell viability relative to pristine PLA and BFO-lined PLA scaffolds. A 48 hours electrical stimulation on the hADMSC cultured inside the 3D-printed BFO-lined PLA scaffolds indicates that stimulated cells are aligned toward the BFO line. These results could indicate the potential of BFO for directing cells toward damaged tissues.
dc.identifier.doi10.1002/pat.5159
dc.identifier.eissn1099-1581
dc.identifier.issn1042-7147
dc.identifier.urihttps://hdl.handle.net/11424/236364
dc.identifier.wosWOS:000584613800001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofPOLYMERS FOR ADVANCED TECHNOLOGIES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject3D printing
dc.subjectbismuth ferrite
dc.subjectcell alignment
dc.subjectelectrical stimulation
dc.subjectneural scaffold
dc.subjectSTIMULATION
dc.subjectCOMPOSITES
dc.subjectTHERAPY
dc.subjectFIELD
dc.titleEffect of electric stimulus on human adipose-derived mesenchymal stem cells cultured in 3D-printed scaffolds
dc.typearticle
dspace.entity.typePublication
local.avesis.id00580b3e-b66f-4827-a35e-504e3f1c5562
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages12
local.journal.quartileQ2
oaire.citation.endPage1125
oaire.citation.issue3
oaire.citation.startPage1114
oaire.citation.titlePOLYMERS FOR ADVANCED TECHNOLOGIES
oaire.citation.volume32
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

Files

Collections

Research Outputs