Publication:
Comparison of conventional chest physiotherapy and oscillatory positive expiratory pressure therapy in primary ciliary dyskinesia

Simple item page
dc.contributor.authorKARADAĞ, BÜLENT TANER
dc.contributor.authorsBingol, Ibrahim; Gokdemir, Yasemin; Yilmaz-Yegit, Cansu; Ergenekon, Pinar; Atag, Emine; Bas Ikizoglu, Nilay; Erdem Eralp, Ela; Evkaya, Ayca; Gencer, Kardelen; Saygi, Evrim K.; Karakoc, Fazilet; Ersu, Refika; Karadag, Bulent
dc.date.accessioned2022-03-12T22:42:07Z
dc.date.available2022-03-12T22:42:07Z
dc.date.issued2020
dc.description.abstractBackground Chest physiotherapy (CP) is a recommended treatment modality in primary ciliary dyskinesia (PCD). Objective Primary aim was to compare the efficacy and safety of the conventional chest physiotherapy (CCP) and oscillatory positive expiratory pressure therapy (OPEPT). Secondary aims were to compare the exacerbation rate, time until the first exacerbation, patient compliance and comfort between the two CP methods. Methods This is a 6 month randomized, controlled crossover trial. Patients >6 years of age with PCD were randomized into two groups, first group was assigned to OPEPT (Acapella (R)) for 3 months while second group was assigned to CCP. Groups were crossed over to the other modality after a 15-day washout period. Pulmonary function tests (PFTs) and compliance were monitored by monthly clinic visits. Results There was a significant increase in FEV1, FEF25-75, and PEF values (p = .018,p = .020, andp = .016, respectively) in the OPEPT group and in FVC values (p = .007) in CCP group compared to baseline. However PFT increase at 3rd month was not superior to each other with both physiotherapy methods. Median acute pulmonary exacerbation rate and time period until the first exacerbation were similar in both groups (p = .821,p = .092, respectively). Comfort and effectiveness of OPEPT was higher than CCP according to patients (p = .029 andp = .042, respectively). There were no adverse effects with either therapy. Conclusions OPEPT was as effective as CCP in PCD patients. OPEPT was more comfortable and effective than CCP according to patients. OPEPT might be an efficient alternative method for airway cleareance in PCD patients.
dc.identifier.doi10.1002/ppul.25099
dc.identifier.eissn1099-0496
dc.identifier.issn8755-6863
dc.identifier.pubmed32997437
dc.identifier.urihttps://hdl.handle.net/11424/236206
dc.identifier.wosWOS:000580650800001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofPEDIATRIC PULMONOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectchest physiotherapy
dc.subjectoscillatory positive expiratory pressure therapy
dc.subjectprimary ciliary dyskinesia
dc.subjectRANDOMIZED CROSSOVER TRIAL
dc.subjectAIRWAY-CLEARANCE THERAPY
dc.subjectQUALITY-OF-LIFE
dc.subjectCYSTIC-FIBROSIS
dc.subjectFLUTTER DEVICE
dc.subjectBRONCHIECTASIS
dc.subjectVALIDATION
dc.subjectINSTRUMENT
dc.subjectADHERENCE
dc.subjectCHILDREN
dc.titleComparison of conventional chest physiotherapy and oscillatory positive expiratory pressure therapy in primary ciliary dyskinesia
dc.typearticle
dspace.entity.typePublication
local.avesis.id2edb279d-0e37-4fb6-9fc1-dfcfc2cb0e95
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ2
oaire.citation.endPage3420
oaire.citation.issue12
oaire.citation.startPage3414
oaire.citation.titlePEDIATRIC PULMONOLOGY
oaire.citation.volume55
relation.isAuthorOfPublication218b489d-97ab-49dd-9db6-0c2a732f1999
relation.isAuthorOfPublication.latestForDiscovery218b489d-97ab-49dd-9db6-0c2a732f1999

Files

Collections

Research Outputs