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Fibrinogen-Aα THR312ALA Polymorphism is Associated to Chronic Thromboembolic Pulmonary Hypertension in Turkey

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dc.contributor.authorYILDIZELİ, BEDRETTİN
dc.contributor.authorsÇörtük M., YILDIZELİ B., Kurar E., Kayış S. A., Tanrıverdi E., Çetinkaya E.
dc.date.accessioned2023-03-21T10:11:33Z
dc.date.available2023-03-21T10:11:33Z
dc.date.issued2023-03-01
dc.description.abstractBACKGROUND: Chronic thromboembolic pulmonary hypertension is a condition that occurs after mechanical obstruction of the pulmonary arteries by thrombus. Since the frequency and demographics of chronic thromboembolic pulmonary hypertension differ between countries, it is thought that genetic factors may play a role in its development. The aim of this study is to reveal the status of VKORC1, CYP2C9*3, CYP2C9*7, and fibrinogen-Aα THR312ALA gene polymorphisms in chronic thromboembolic pulmonary hypertension patients in Turkey. METHODS: In this prospective cross-sectional study, a total of 46 chronic thromboembolic pulmonary hypertension patients and 106 healthy volunteers were included. Polymerase chain reaction-restriction fragment length polymorphism method was used to determine candidate gene polymorphisms for chronic thromboembolic pulmonary hypertension. The general population parameters of each locus were calculated, and the relationship between dominant, codominant, and recessive genotype models and chronic thromboembolic pulmonary hypertension was analyzed. RESULTS: For the fibrinogen-Aα gene, those with the THR/THR genotype were found to have a 13.51 (95% CI: 2.688-33.333) times less susceptibility rate to the disease than those with the ALA/THR genotype, the susceptibility of THR/ALA genotype to the disease was 5.026 (95% CI: 1.774-14.242) times more than those with ALA/ALA genotype. There was no difference between patient groups for VKORC1, CYP2C9*3 genes (P >.05). Since the CYP2C9*7 patient group was monomorphic for the ILE allele, the patient/control odds ratio and 95% CI could not be calculated. CONCLUSION: This study shows that there is an association between the fibrinogen-Aα gene ALA polymorphism at the amino acid position of 312 and the development of chronic thromboembolic pulmonary hypertension, but not between the CYP2C9 and VKORC1 gene polymorphisms.
dc.identifier.citationÇörtük M., YILDIZELİ B., Kurar E., Kayış S. A., Tanrıverdi E., Çetinkaya E., "Fibrinogen-Aα THR312ALA Polymorphism is Associated to Chronic Thromboembolic Pulmonary Hypertension in Turkey", Anatolian journal of cardiology, cilt.27, sa.3, ss.153-159, 2023
dc.identifier.doi10.14744/anatoljcardiol.2022.2392
dc.identifier.endpage159
dc.identifier.issn2149-2271
dc.identifier.issue3
dc.identifier.startpage153
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/d0c36d7a-6bcc-4100-89d6-b0513b1c83ec/file
dc.identifier.urihttps://hdl.handle.net/11424/287703
dc.identifier.volume27
dc.language.isoeng
dc.relation.ispartofAnatolian journal of cardiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectKardiyoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectCardiovascular
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKALP VE KALP DAMAR SİSTEMLERİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectCARDIAC & CARDIOVASCULAR SYSTEMS
dc.subjectKardiyoloji ve Kardiyovasküler Tıp
dc.subjectCardiology and Cardiovascular Medicine
dc.titleFibrinogen-Aα THR312ALA Polymorphism is Associated to Chronic Thromboembolic Pulmonary Hypertension in Turkey
dc.typearticle
dspace.entity.typePublication
local.avesis.idd0c36d7a-6bcc-4100-89d6-b0513b1c83ec
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationd6b68c67-eea7-4dc3-8688-e8cfbe3bbcd2
relation.isAuthorOfPublication.latestForDiscoveryd6b68c67-eea7-4dc3-8688-e8cfbe3bbcd2

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