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British Oncology Pharmacy Association Delphi consensus guidelines: Co-infusion of trometamol-containing calcium folinate (Leucovorin) with systemic anti-cancer treatments

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dc.contributor.authorTEZCAN, SONGÜL
dc.contributor.authorsPolwart C., Root T., TEZCAN S., Meehan S., Wetherill B., Waterson C., Burnett B., Chauhan R., Al-Modaris I.
dc.date.accessioned2024-04-22T16:49:38Z
dc.date.available2024-04-22T16:49:38Z
dc.date.issued2024-01-01
dc.description.abstractDrug stability and compatibility are critical factors influencing the cost and logistics of treatment delivery, therapeutic effectiveness, and patient safety. This is particularly significant in the realm of cancer chemotherapeutics, where stability and compatibility studies play a vital role in ensuring rational and safe medicine administration. Oxaliplatin, fluorouracil, and irinotecan, commonly used in various combinations for gastrointestinal cancers, are complemented by co-administration of folinic acid in certain protocols. Notably, some folinic acid preparations include trometamol as an excipient, potentially impacting the stability of the chemotherapeutic agents if infused concomitantly. This study seeks to establish guidelines for oncology multidisciplinary teams, addressing potential risks associated with the combination of trometamol-containing folinic acid and chemotherapeutics. To achieve this, a quantitative questionnaire was distributed to members of the British Oncology Pharmacy Association (BOPA) and non-BOPA members through an online survey. Nineteen healthcare professionals with oncology experience, comprising 18 pharmacists and one nurse, completed the questionnaires. Each participant rated the validity and clarity of statements on a 5-point scale. The Delphi process concluded after the fourth round, consolidating the findings and recommendations from the multidisciplinary team. Twelve recommendations for safe practice have been made.
dc.identifier.citationPolwart C., Root T., TEZCAN S., Meehan S., Wetherill B., Waterson C., Burnett B., Chauhan R., Al-Modaris I., "British Oncology Pharmacy Association Delphi consensus guidelines: Co-infusion of trometamol-containing calcium folinate (Leucovorin) with systemic anti-cancer treatments", Journal of Oncology Pharmacy Practice, 2024
dc.identifier.doi10.1177/10781552241243360
dc.identifier.issn1078-1552
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85189957372&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/296657
dc.language.isoeng
dc.relation.ispartofJournal of Oncology Pharmacy Practice
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectTemel Eczacılık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectBasic Pharmaceutics Sciences
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectOncology
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectONKOLOJİ
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectONCOLOGY
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectFarmakoloji (tıbbi)
dc.subjectPharmacology (medical)
dc.subjectCalcium folinate
dc.subjectcompatibility
dc.subjectdrug administration
dc.subjectfolinic acid
dc.subjectirinotecan
dc.subjectLeucovorin
dc.subjectoxaliplatin
dc.subjecttrometamol
dc.titleBritish Oncology Pharmacy Association Delphi consensus guidelines: Co-infusion of trometamol-containing calcium folinate (Leucovorin) with systemic anti-cancer treatments
dc.typearticle
dspace.entity.typePublication
local.avesis.idaac5294b-c1fe-4a56-a054-5c34ea2057b4
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationc85f4f45-754c-4afe-b4c8-a2676625355f
relation.isAuthorOfPublication.latestForDiscoveryc85f4f45-754c-4afe-b4c8-a2676625355f

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