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Androgen-deprivation therapy impairs left ventricle functions in prostate cancer patients

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dc.contributor.authorÖZBEN SADIÇ, BESTE
dc.contributor.authorsKanar, Batur Gonenc; Ozben, Beste; Sunbul, Murat; Sener, Emre; Ozkan, Onur; Tinay, Ilker; Tigen, Mustafa Kursat
dc.date.accessioned2022-03-12T22:29:39Z
dc.date.available2022-03-12T22:29:39Z
dc.date.issued2019
dc.description.abstractBackgroundAndrogen-deprivation therapy (ADT) is a treatment option for locally advanced and metastatic prostate cancer (PCA). The aim of the study was to evaluate the effect of ADT on left ventricular (LV) functions assessed by speckle-tracking echocardiography (STE) in prostate cancer (PCA) patients.MethodsForty-nine consecutive PCA patients (mean age 71.56.7years) who would be treated with radiotherapy and ADT and 32 consecutive PCA patients (mean age 71.97.0years) who would be treated with radical or partial prostatectomy and 42 age-matched healthy men (mean age 70.5 +/- 9.1years) were included in our study. The left ventricular functions were assessed by both conventional echocardiography and STE at baseline and 6months later.ResultsThere were not any significant difference in characteristics of the patients and controls. There were not any significant differences in conventional echocardiographic measures at baseline and at 6th month among the PCA patients and controls. Although there were not any significant differences in STE measures at baseline among the PCA patients and controls, the strain measures of the PCA patients receiving ADT decreased significantly at the 6th month and were significantly lower compared to strain measures of PCA patients undergoing prostatectomy and controls. There was not any statistically significant difference in baseline and 6th-month strain measures of the PCA patients undergoing prostatectomy.Conclusions<ADT might be associated with decrease in LV longitudinal, circumferential, and radial strain measures in patients with PCA. STE might be useful for early identification of LV subclinical impairment in PCA patients treated with ADT.
dc.identifier.doi10.1007/s11255-019-02184-4
dc.identifier.eissn1573-2584
dc.identifier.issn0301-1623
dc.identifier.pubmed31165396
dc.identifier.urihttps://hdl.handle.net/11424/235397
dc.identifier.wosWOS:000474214700004
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofINTERNATIONAL UROLOGY AND NEPHROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAndrogen-deprivation therapy
dc.subjectEchocardiography
dc.subjectProstate cancer
dc.subjectTestosterone
dc.subjectAMERICAN SOCIETY
dc.subjectEUROPEAN ASSOCIATION
dc.subjectTESTOSTERONE
dc.subjectECHOCARDIOGRAPHY
dc.subjectRECOMMENDATIONS
dc.subjectMORTALITY
dc.subjectSTEROIDS
dc.subjectUPDATE
dc.subjectMEN
dc.titleAndrogen-deprivation therapy impairs left ventricle functions in prostate cancer patients
dc.typearticle
dspace.entity.typePublication
local.avesis.idc521a19a-ec56-457b-b490-5cd7cad1ced3
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
local.journal.quartileQ3
oaire.citation.endPage1112
oaire.citation.issue7
oaire.citation.startPage1107
oaire.citation.titleINTERNATIONAL UROLOGY AND NEPHROLOGY
oaire.citation.volume51
relation.isAuthorOfPublicationa3b8b4a2-fc05-4f42-b6ec-5a452471f501
relation.isAuthorOfPublication.latestForDiscoverya3b8b4a2-fc05-4f42-b6ec-5a452471f501

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