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Bactericidal Permeability Increasing Protein Gene Polymorphism is Associated with Inflammatory Bowel Diseases in the Turkish Population

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dc.contributor.authorEREN, FATİH
dc.contributor.authorsCan, Guray; Akin, Hakan; Ozdemir, Filiz T.; Can, Hatice; Yilmaz, Bulent; Eren, Fatih; Atug, Ozlen; Unsal, Belkis; Hamzaoglu, Hulya O.
dc.date.accessioned2022-03-14T11:05:34Z
dc.date.available2022-03-14T11:05:34Z
dc.date.issued2015
dc.description.abstractBackground/Aims: Inflammatory bowel disease, a chronic inflammatory disease with unknown etiology, affects the small and large bowel at different levels. It is increasingly considered that innate immune system may have a central position in the pathogenesis of the disease. As a part of the innate immune system, bactericidal permeability increasing protein has an important role in the recognition and neutralization of gram-negative bacteria. The aim of our study was to investigate the involvement of bactericidal permeability increasing protein gene polymorphism (bactericidal permeability increasing protein Lys216Glu) in inflammatory bowel disease in a large group of Turkish patients. Patients and Methods: The present study included 528 inflammatory bowel disease patients, 224 with Crohn's disease and 304 with ulcerative colitis, and 339 healthy controls. Results: Bactericidal permeability increasing protein Lys216Glu polymorphism was found to be associated with both Crohn's disease and ulcerative colitis (P = 0.0001). The frequency of the Glu/Glu genotype was significantly lower in patients using steroids and in those with steroid dependence (P = 0.012, OR, 0.80; 95% confidence interval [CI]: 0.68-0.94; P = 0.0286, OR, 0.75; 95% CI: 0.66-0.86, respectively). There was no other association between bactericidal permeability increasing protein gene polymorphism and phenotypes of inflammatory bowel disease. Conclusions: Bactericidal permeability increasing protein Lys216Glu polymorphism is associated with both Crohn's disease and ulcerative colitis. This is the first study reporting the association of bactericidal permeability increasing protein gene polymorphism with steroid use and dependence in Crohn's disease.
dc.identifier.doi10.4103/1319-3767.161642
dc.identifier.eissn1998-4049
dc.identifier.issn1319-3767
dc.identifier.pubmed26228368
dc.identifier.urihttps://hdl.handle.net/11424/245868
dc.identifier.wosWOS:000358778800010
dc.language.isoeng
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTD
dc.relation.ispartofSAUDI JOURNAL OF GASTROENTEROLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBactericidal permeability increasing protein
dc.subjectinflammatory bowel disease
dc.subjectsingle nucleotide polymorphism
dc.subjectCROHNS-DISEASE
dc.subjectULCERATIVE-COLITIS
dc.subjectBPI GENE
dc.subjectMUTATION
dc.subjectSUSCEPTIBILITY
dc.subjectVARIANTS
dc.subjectFRAGMENT
dc.subjectTOLL
dc.titleBactericidal Permeability Increasing Protein Gene Polymorphism is Associated with Inflammatory Bowel Diseases in the Turkish Population
dc.typearticle
dspace.entity.typePublication
local.avesis.idfbaacb9e-2bea-4bda-acb6-de43ad8d8b36
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages6
oaire.citation.endPage244
oaire.citation.issue4
oaire.citation.startPage239
oaire.citation.titleSAUDI JOURNAL OF GASTROENTEROLOGY
oaire.citation.volume21
relation.isAuthorOfPublication4bc77d63-5aa7-4c67-8d60-12778ea963b1
relation.isAuthorOfPublication.latestForDiscovery4bc77d63-5aa7-4c67-8d60-12778ea963b1

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