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Distribution of Zonula Occludens-1 and Occludin and alterations of testicular morphology after in utero radiation and postnatal hyperthermia in rats

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsSenturk, Gozde Erkanli; Canillioglu, Yasemin Ersoy; Umay, Cenk; Demiralp-Eksioglu, Emel; Ercan, Feriha
dc.date.accessioned2022-03-14T10:53:03Z
dc.date.available2022-03-14T10:53:03Z
dc.date.issued2012-12
dc.description.abstractIn utero irradiation (IR) and postnatal hyperthermia (HT) exposure cause infertility by decreasing spermatogenic colony growth and the number of sperm in rats. Four groups were used: (i) Control group, (ii) HT group (rats exposed to hyperthermia on the 10th postnatal day), (iii) IR group (rats exposed to IR on the 17th gestational day) and (iv) IR + HT group. Three and six months after the procedures testes were examined by light and electron microscopy. Some degenerated tubules in the HT group, many vacuoles in spermatogenic cells and degenerated tight junctions in the IR group, atrophic tubules and severe degeneration of tight junctions in the IR + HT group were observed. ZO-1 and occludin immunoreactivity were decreased and disorganized in the HT and IR groups and absent in the IR + HT group. The increase in the number of apoptotic cells was accompanied by a time-dependent decrease in haploid, diploid and tetraploid cells in all groups. Degenerative findings were severe after 6 months in all groups. The double-hit model may represent a Sertoli cell only model of infertility due to a decrease in spermatogenic cell and alterated blood-testis barrier proteins in rat.
dc.identifier.doi10.1111/j.1365-2613.2012.00844.x
dc.identifier.eissn1365-2613
dc.identifier.issn0959-9673
dc.identifier.pubmed23136996
dc.identifier.urihttps://hdl.handle.net/11424/245273
dc.identifier.wosWOS:000310875300007
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofINTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectapoptosis
dc.subjectblood-testis barrier
dc.subjecthyperthermia
dc.subjectirradiation
dc.subjectrat
dc.subjecttestis
dc.subjectSEMINIFEROUS TUBULES
dc.subjectSINGLE EXPOSURE
dc.subjectCELL-DEATH
dc.subjectTESTIS
dc.subjectSERTOLI
dc.subjectSPERMATOGENESIS
dc.subjectAPOPTOSIS
dc.subjectIRRADIATION
dc.subjectEXPRESSION
dc.subjectHEAT
dc.titleDistribution of Zonula Occludens-1 and Occludin and alterations of testicular morphology after in utero radiation and postnatal hyperthermia in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.ida75190bc-7265-49ec-8673-d97a188b688c
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages12
oaire.citation.endPage449
oaire.citation.issue6
oaire.citation.startPage438
oaire.citation.titleINTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
oaire.citation.volume93
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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