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Characteristics of periodontal microflora in acute myocardial infarction

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dc.contributor.authorDOĞAN, BAŞAK
dc.contributor.authorsDogan, B; Buduneli, E; Emingil, G; Atilla, G; Akilli, A; Antinheimo, J; Lakio, L; Asikainen, S
dc.date.accessioned2022-03-12T17:22:37Z
dc.date.available2022-03-12T17:22:37Z
dc.date.issued2005
dc.description.abstractBackground: Periodontitis has been linked to increased risk of cardiovascular diseases. Systemic reactions associated with cardiovascular events may depend on characteristics of the subgingival microflora in periodontitis. Our objectives were to compare the numbers of cultivable bacteria, composition of subgingival microflora and clonal distribution of Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) in two groups of patients with generalized chronic periodontitis (GCP), one with an acute myocardial infarction (AMI-GCP) and the other one without AMI (non-AMI-GCP). Methods: In all, 150 dentate individuals were screened for suitability to this study. Subgingival bacterial samples were collected from 11 AMI-GCP and 11 non-AMI-GCP patients who had been selected using strict inclusion criteria in an attempt to exclude confounding factors and to increase comparability of periodontal conditions by matching for periodontal probing depths and attachment levels. Culture methods were used to determine the total viable counts and occurrence and proportions of six periodontal bacterial species and yeasts. Polymerase chain reaction (PCR) technique was used to detect A. actinomycetemcomitans and Porphyromonas gingivalis (P. gingivalis). Intraspecies characterization of A. actinomycetemcomitans included serotyping and genotyping. Results: The mean proportions of P gingivalis (P = 0.05) and Tannerella forsythensis (T forsythensis) (P = 0.01) were significantly lower, but the numbers of Micromonas micros (M. micros) and A. actinomycetemcomitans were up to nine times higher and the mean total number of cultivable bacteria per sample higher (P < 0.01) in AMI-GCP than in non-AMI-GCP. Conclusion: The findings that no target subgingival species were overrepresented but the total bacterial number was higher in AMI-GCP than non-AMI-GCP patients may provide support to the hypothesis that elevated numbers of bacteria in close vicinity to sterile parenteral area present a risk for systemic health.
dc.identifier.doi10.1902/jop.2005.76.5.740
dc.identifier.eissn1943-3670
dc.identifier.issn0022-3492
dc.identifier.pubmed15898935
dc.identifier.urihttps://hdl.handle.net/11424/228429
dc.identifier.wosWOS:000229299800012
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF PERIODONTOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectActinobacillus actinomycetemcomitans
dc.subjectgenotype
dc.subjectmyocardial infarction
dc.subjectperiodontitis/pathogenesis
dc.subjectPorphyromonas gingivalis
dc.subjectserotype
dc.subjectACTINOBACILLUS-ACTINOMYCETEMCOMITANS SEROTYPES
dc.subjectLOCALIZED JUVENILE PERIODONTITIS
dc.subjectPOLYMERASE-CHAIN-REACTION
dc.subjectCORONARY-ARTERY-DISEASE
dc.subjectPORPHYROMONAS-GINGIVALIS
dc.subjectSUBGINGIVAL MICROBIOTA
dc.subjectBACTEROIDES-INTERMEDIUS
dc.subjectINFECTION
dc.subjectADULT
dc.subjectATHEROSCLEROSIS
dc.titleCharacteristics of periodontal microflora in acute myocardial infarction
dc.typearticle
dspace.entity.typePublication
local.avesis.id7ecd9760-50b4-411a-a3cc-26bbc4e1f9f9
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
oaire.citation.endPage748
oaire.citation.issue5
oaire.citation.startPage740
oaire.citation.titleJOURNAL OF PERIODONTOLOGY
oaire.citation.volume76
relation.isAuthorOfPublicationa2569f78-7a2a-4f98-8cc9-d8b67ae56f6d
relation.isAuthorOfPublication.latestForDiscoverya2569f78-7a2a-4f98-8cc9-d8b67ae56f6d

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