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Long-term respiratory outcomes of post-op congenital lung malformations

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dc.contributor.authorKARADAĞ, BÜLENT TANER
dc.contributor.authorsDincel, Alican; Yilmaz Yegit, Cansu; Ergenekon, Almala Pinar; Erdem Eralp, Ela; Gokdemir, Yasemin; Kiyan, Gursu; Karadag, Bulent
dc.date.accessioned2022-03-12T22:55:36Z
dc.date.available2022-03-12T22:55:36Z
dc.date.issued2021
dc.description.abstractBackground Congenital lung malformations (CLM) are rare disorders and surgical intervention is the definitive treatment. Our aim is to evaluate the long-term lung function of patients with CLM after surgery compared to healthy children. Methods Sixteen children with CLM (M/F: 9/7) and 30 age-matched, healthy controls (M/F: 13/17) were included in the study. Demographic data were recorded and both groups were compared by spirometry and the nitrogen-based Lung Clearance Index (LCI). Results Mean +/- SD age of the patients was 12.0 +/- 5.4 years. The mean forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and forced expiratory flow between 25% and 75% of force expiration (FEF25-75) predicted was, 86.68 +/- 16.65, 88.00 +/- 14.58, 97.44 +/- 9.89, and 79.00 +/- 26.41, respectively in the patient group. Patients with CLM had significantly lower values in FEV1, FVC, FEF25-75 than healthy controls (P = 0.002, P 0.007, P 0.045). While the mean LCI2,5% value in patients' group was 8.33 +/- 1.52, it was 7.28 +/- 0.80 in healthy controls (P = 0.023). Strong inverse correlation between LCI and FEV1, FEV1/FVC was detected in the patient group (P = 0.023; r: -0.581, P 0.017; r: -0.606 respectively). Conclusion This study revealed that, in long-term follow-up, patients who had surgery because of CLM have impairment in the pulmonary function compared to healthy children and LCI may be more accurate in detecting airway diseases early than spirometry.
dc.identifier.doi10.1111/ped.14488
dc.identifier.eissn1442-200X
dc.identifier.issn1328-8067
dc.identifier.pubmed32991002
dc.identifier.urihttps://hdl.handle.net/11424/236787
dc.identifier.wosWOS:000654380100001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofPEDIATRICS INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcongenital lung malformations
dc.subjectlung clearance index
dc.subjectpulmonary function test
dc.subjectspirometry
dc.subjectINERT-GAS WASHOUT
dc.subjectMULTIPLE-BREATH WASHOUT
dc.subjectPULMONARY-FUNCTION
dc.subjectCLEARANCE INDEX
dc.subjectCHILDREN
dc.subjectLOBECTOMY
dc.subjectDISEASE
dc.subjectSTATEMENT
dc.subjectCHILDHOOD
dc.subjectRESECTION
dc.titleLong-term respiratory outcomes of post-op congenital lung malformations
dc.typearticle
dspace.entity.typePublication
local.avesis.id4e444ff5-aa2b-46fd-bc8a-a367b3c36a3a
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage709
oaire.citation.issue6
oaire.citation.startPage704
oaire.citation.titlePEDIATRICS INTERNATIONAL
oaire.citation.volume63
relation.isAuthorOfPublication218b489d-97ab-49dd-9db6-0c2a732f1999
relation.isAuthorOfPublication.latestForDiscovery218b489d-97ab-49dd-9db6-0c2a732f1999

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