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Serum osteocalcin levels in patients with nonalcoholic fatty liver disease: Association with ballooning degeneration

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dc.contributor.authorEREN, FATİH
dc.contributor.authorsYilmaz, Yusuf; Kurt, Ramazan; Eren, Fatih; Imeryuz, Nese
dc.date.accessioned2022-03-12T17:50:57Z
dc.date.available2022-03-12T17:50:57Z
dc.date.issued2011
dc.description.abstractOur aim was to examine the relation of serum osteocalcin (OCN) levels with the clinical, biochemical, and histological characteristics of patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD). We carried out a case-control study including 99 patients with biopsy-proven NAFLD and 75 age-and sex-matched controls. Concentrations of OCN were measured in aprotinin-treated serum samples using a solid-phase enzyme amplified sensitivity immunoassay. Serum OCN levels were significantly lower in patients with NAFLD than in healthy controls. In patients with NAFLD, serum OCN levels were inversely associated with ALT (r = -0.36, p < 0.001), AST (r = -0.39, p < 0.001), HOMA-IR (r = -0.30, p < 0.01) and the degree of hepatocyte ballooning (r = -0.20, p < 0.05). Serum OCN was the only independent predictor of the degree of hepatocyte ballooning in NAFLD patients (beta = -0.24; t = -2.146, p < 0.05). Compared with controls, NAFLD patients have a decrease in serum OCN concentrations, which is significantly associated with serum transaminases and the extent of hepatocyte ballooning.
dc.identifier.doi10.3109/00365513.2011.604427
dc.identifier.issn0036-5513
dc.identifier.pubmed21859358
dc.identifier.urihttps://hdl.handle.net/11424/230235
dc.identifier.wosWOS:000296980600002
dc.language.isoeng
dc.publisherINFORMA HEALTHCARE
dc.relation.ispartofSCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOsteocalcin
dc.subjectnonalcoholic fatty liver disease
dc.subjecthepatocyte ballooning
dc.subjectMETABOLIC SYNDROME
dc.subjectINSULIN-RESISTANCE
dc.subjectSTEATOHEPATITIS
dc.subjectSECRETION
dc.subjectGLUCOSE
dc.subjectMEN
dc.titleSerum osteocalcin levels in patients with nonalcoholic fatty liver disease: Association with ballooning degeneration
dc.typearticle
dspace.entity.typePublication
local.avesis.id79526d2f-a086-41a2-8a26-d0cbf0a9a82f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage636
oaire.citation.issue8
oaire.citation.startPage631
oaire.citation.titleSCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
oaire.citation.volume71
relation.isAuthorOfPublication4bc77d63-5aa7-4c67-8d60-12778ea963b1
relation.isAuthorOfPublication.latestForDiscovery4bc77d63-5aa7-4c67-8d60-12778ea963b1

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