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The methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley rats

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dc.contributor.authorÇAM, MUHAMMET EMİN
dc.contributor.authorYAVUZ, AYŞE NUR
dc.contributor.authorTAŞKIN, TURGUT
dc.contributor.authorKABASAKAL, LEVENT
dc.contributor.authorELÇİOĞLU, HATİCE KÜBRA
dc.contributor.authorsSermet S., ÇAM M. E., YAVUZ A. N., TAŞKIN T., Kabatas G. S., YAZIR Y., KABASAKAL L., ELÇİOĞLU H. K.
dc.date.accessioned2023-11-27T08:48:07Z
dc.date.available2023-11-27T08:48:07Z
dc.date.issued2023-12-01
dc.description.abstractBackground: Teucrium polium and Micromeria fruticosa subspecies are known to be used in traditional medicine for diabetes treatment. Objective: The present study aimed to examine the potential antidiabetic effects and the mechanisms of antidiabetic actions of Teucrium polium L. methanolic extract (TP) and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis methanolic extract (MF) on rats with type 2 diabetes mellitus (DM). Methods: Streptozotocin (STZ) and nicotinamide (NA) were injected intraperitoneally to induce type 2 diabetes mellitus (T2DM) in rats. Plant extracts’ antidiabetic mechanisms of action were investigated with biochemical analyses and histopathological analyses performed. Results: TP and MF treatments reduced the blood glucose levels compared to the untreated diabetic rats. TP reduced TNF-α levels in serum, increased insulin levels in serum and pancreas, reduced SGLT-2 levels in kidneys, reduced GLUT-2 levels in the ileum; and MF reduced TNF-α levels, and increased insulin levels in serum and pancreas, increased GLP-1 levels, and reduced GLUT-2 levels in the ileum, and reduced SGLT-2 levels in kidneys. Treatments improved the histopathological results in the pancreas, kidney, and liver. Conclusions: The results presented in this study demonstrated that TP and MF both have potential antidiabetic effects and may be effective in T2DM treatment.
dc.identifier.citationSermet S., ÇAM M. E., YAVUZ A. N., TAŞKIN T., Kabatas G. S., YAZIR Y., KABASAKAL L., ELÇİOĞLU H. K., "The methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley rats", Obesity Medicine, cilt.44, 2023
dc.identifier.doi10.1016/j.obmed.2023.100517
dc.identifier.issn2451-8476
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85176929023&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/295153
dc.identifier.volume44
dc.language.isoeng
dc.relation.ispartofObesity Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectSosyoloji
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectEndocrinology and Metabolic Diseases
dc.subjectSocial Sciences and Humanities
dc.subjectSociology
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectSosyal Bilimler (SOC)
dc.subjectKlinik Tıp
dc.subjectSosyal Bilimler Genel
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectKAMU, ÇEVRE VE İŞ SAĞLIĞI
dc.subjectClinical Medicine (MED)
dc.subjectSocial Sciences (SOC)
dc.subjectCLINICAL MEDICINE
dc.subjectSOCIAL SCIENCES, GENERAL
dc.subjectENDOCRINOLOGY & METABOLISM
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
dc.subjectDahiliye
dc.subjectEndokrinoloji, Diyabet ve Metabolizma
dc.subjectHalk, Çevre ve İş Sağlığı
dc.subjectInternal Medicine
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectAntidiabetic
dc.subjectMedicinal plants
dc.subjectMicromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis
dc.subjectTeucrium polium L.
dc.subjectType 2 diabetes mellitus
dc.titleThe methanolic extracts of Teucrium polium L. and Micromeria fruticosa (L.) Druce subsp. brachycalyx P. H. Davis improve diabetes in streptozotocin/nicotinamide-induced type 2 diabetic female Sprague Dawley rats
dc.typearticle
dspace.entity.typePublication
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