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Hippocampal kindling in rats with absence epilepsy resembles amygdaloid kindling

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsAkman, Ozlem; Karson, Ayse; Aker, Rezzan Gulhan; Ates, Nurbay; Onat, Filiz Yilmaz
dc.date.accessioned2022-03-12T17:34:17Z
dc.date.available2022-03-12T17:34:17Z
dc.date.issued2008
dc.description.abstractPurpose: WAG/Rij and GAERS rats show delays or resistance to secondary generalization of limbic seizures during amygdaloid kindling. In this study, we aimed to evaluate the kindling from a different limbic site, hippocampus, and to compare its effects on spike-and-wave discharges (SWDs) with that of amygdaloid kindling. Methods: Recording electrodes were implanted epidurally and a stimulation/recording electrode was implanted into the ventral hippocampus in the WAG/Rij, GAERS and Wistar rats. Animals received kindling stimulation twice daily at their afterdischarge thresholds until they reached stage 5 seizures, or the maximum number of stimulations (50) had been delivered. The EEG was recorded to analyze SWDs and afterdischarge durations. Results: All Wistar rats reached stage 5 by the 34th stimulation. 4 of 8 WAG/Rij rats and 3 of 6 GAERS rats displayed stage 4/5 seizures (kindling-prone rats); the rest stayed at stage 2 seizures (kindling-resistant rats) even after 50th stimulations. The cumulative duration and number of SWDs decreased in the post-stimulation period after the first stage 2 seizures, whereas these parameters increased after the first stage 3 seizures in the kindling-prone WAG/Rij and GAERS. The peak frequency of SWDs and its harmonics decreased significantly only in the GAERS group after stage 4 seizures. Conclusion: Hippocampal kindling resembles amygdaloid kindling in showing a delay of or resistance to secondary seizure generalization, which supported the interaction of thalamo-cortical and limbic circuitry in GAERS and WAG/Rij. (C) 2008 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.eplepsyres.2008.06.004
dc.identifier.eissn1872-6844
dc.identifier.issn0920-1211
dc.identifier.pubmed18657396
dc.identifier.urihttps://hdl.handle.net/11424/228999
dc.identifier.wosWOS:000261021000016
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofEPILEPSY RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGeneralized epilepsy
dc.subjectWAG/Rij
dc.subjectGAERS
dc.subjectTemporal lobe epilepsy model
dc.subjectPartial epilepsy
dc.subjectKindling resistance
dc.subjectNUCLEUS-REUNIENS-THALAMI
dc.subjectFERRITIN HEAVY-CHAIN
dc.subjectELECTRICAL-STIMULATION
dc.subjectBIDIRECTIONAL TRANSFER
dc.subjectPERIRHINAL CORTEX
dc.subjectSEIZURES
dc.subjectBRAIN
dc.subjectMECHANISMS
dc.subjectEXPRESSION
dc.subjectMODEL
dc.titleHippocampal kindling in rats with absence epilepsy resembles amygdaloid kindling
dc.typearticle
dspace.entity.typePublication
local.avesis.ideeea5c54-ab05-4e0a-bf9e-60f2338b43ad
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
oaire.citation.endPage219
oaire.citation.issue2-3
oaire.citation.startPage211
oaire.citation.titleEPILEPSY RESEARCH
oaire.citation.volume81
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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