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Investigation of Antioxidants's Antimutagenic Effects by The Ames Test

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dc.contributor.authorBECEREN, AYFER
dc.contributor.authorsBeceren, Ayfer; Sarikaya, Betul; Tatlipinar, Esref; Omurtag, Gulden Z.; Sardas, Semra
dc.date.accessioned2022-03-14T08:27:00Z
dc.date.available2022-03-14T08:27:00Z
dc.date.issued2017-04-18
dc.description.abstractNowadays, several test systems have been developed in order to observe the mutagenic effects of chemical agents which play crucial roles in human health. The Ames Test is one of these test systems. With the Ames Test, some bacterial mutants have been discovered to investigate the mutagenic effects of the chemicals. Various strains of Salmonella typhimurium are one of the groups of the bacterial mutants in question. The aim of this study is to investigate possible antimutagenic effect of Pelargonium sidoides which have an antioxidant effect towards carcinogenic substance called 2-aminofluorene by Ames/Salmonella/Microsome test kit in the absence and presence of metabolic activation. TA 98 and TA 100 strains were used in these experiments. TA 98 is designed for frame-shift mutagens and TA 100 is designed for base-pair mutagens. The antimutagenic activity was screened in two groups with or without S9 metabolic activation. The results were evaluated the mean average values and compared with positive and negative controls. In conclusion, it was shown that Pelargonium sidoides have antimutagenic effect towards TA 98 and TA 100 without S9 metabolic activation (p >= 0.05) but have no antimutagenic effect towards TA 98 and TA 100 with S9 metabolic activation (p <= 0.05).
dc.identifier.doi10.12991/marupj.306790
dc.identifier.issn1309-0801
dc.identifier.urihttps://hdl.handle.net/11424/241802
dc.identifier.wosWOS:000417368400005
dc.language.isotur
dc.publisherMARMARA UNIV, FAC PHARMACY
dc.relation.ispartofMARMARA PHARMACEUTICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAmes test
dc.subjectantioxidant
dc.subjectPelargonium sidoides
dc.subjectS9 fraction
dc.subjectmutagenicity
dc.subjectPELARGONIUM-SIDOIDES
dc.subjectMUTAGENICITY
dc.subjectASSAY
dc.subjectANTIBACTERIAL
dc.subjectPERFORMANCE
dc.subjectRENIFORME
dc.subjectRESPONSES
dc.titleInvestigation of Antioxidants's Antimutagenic Effects by The Ames Test
dc.typearticle
dspace.entity.typePublication
local.avesis.id5fd07ab1-257b-4b0a-b9fe-734c280ab902
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages6
oaire.citation.endPage460
oaire.citation.issue3
oaire.citation.startPage455
oaire.citation.titleMARMARA PHARMACEUTICAL JOURNAL
oaire.citation.volume21
relation.isAuthorOfPublication759fae37-2af1-47e6-92f8-545c02df272b
relation.isAuthorOfPublication.latestForDiscovery759fae37-2af1-47e6-92f8-545c02df272b

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