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Effect of ketone bodies on viability of human breast cancer cells (MCF-7)

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dc.contributor.authorYALÇIN, AHMET SUHA
dc.contributor.authorsKaya, Zuhal; Yilmaz, Ayse Mine; Yalcin, A. Suha
dc.date.accessioned2022-03-14T09:03:21Z
dc.date.available2022-03-14T09:03:21Z
dc.date.issued2018-06-05
dc.description.abstractObjective: Cancer cells exhibit an elevated glycolytic phenotype under aerobic conditions, which is known as the Warburg effect. Recent studies have also shown that cancer cells are glucose-dependent and cannot use ketone bodies as a primary source of energy. In this study, we have investigated the effects of ketone bodies on viability of breast cancer cells considering that breast cancer cells would not use ketone bodies as a primary energy source. Materials and Methods: In this study we have used MCF-7 cells, which are breast cancer cells that cannot use ketone bodies as a primary energy source and human foreskin fibroblast cells (HFF) as controls. We measured cell viability in both cells cultured in the presence or absence of glucose as well as the ketone bodies acetoacetate and beta-hydroxybutyrate. Results: Cell viability was significantly decreased in response to ketone bodies compared with control media in MCF-7 cells whereas in control cells (HFF) cell viability was not changed. Conclusion: In light of the data obtained, we suggest that dietary manipulation with the use of ketone bodies may be a new therapeutic strategy for breast cancer.
dc.identifier.doi10.5472/marumj.430783
dc.identifier.issn1309-9469
dc.identifier.urihttps://hdl.handle.net/11424/242260
dc.identifier.wosWOS:000442050300001
dc.language.isoeng
dc.publisherMARMARA UNIV, FAC MEDICINE
dc.relation.ispartofMARMARA MEDICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcetoacetate
dc.subjectBeta-hydroxybutyrate
dc.subjectketone bodies
dc.subjectMCF-7 cancer cells
dc.subjectMITOCHONDRIA
dc.subjectMETABOLISM
dc.titleEffect of ketone bodies on viability of human breast cancer cells (MCF-7)
dc.typearticle
dspace.entity.typePublication
local.avesis.idf34278ab-2537-4f55-ada6-3e04cfb57b56
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages4
oaire.citation.endPage60
oaire.citation.issue2
oaire.citation.startPage57
oaire.citation.titleMARMARA MEDICAL JOURNAL
oaire.citation.volume31
relation.isAuthorOfPublication7a2bc583-aab6-43e7-9cc3-0d7a60773409
relation.isAuthorOfPublication.latestForDiscovery7a2bc583-aab6-43e7-9cc3-0d7a60773409

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