Publication:
Cytokine Adsorption in Critically Ill COVID-19 Patients, a Case-Control Study

Simple item page
dc.contributor.authorABDULLAYEV, RUSLAN
dc.contributor.authorBİLGİLİ, BELİZ
dc.contributor.authorSEVEN, SEDA
dc.contributor.authorCİNEL, İSMAİL HAKKI
dc.contributor.authorGÜL, FETHİ
dc.contributor.authorsAbdullayev R., Gül F., Bilgili B., Seven S., Cinel I.
dc.date.accessioned2023-03-27T08:25:04Z
dc.date.available2023-03-27T08:25:04Z
dc.date.issued2022-09-01
dc.description.abstractAim: New coronavirus disease (COVID-19) has become an international emergency. As many of the intensive care unit (ICU) patients with the disease also present multiple organ failure, blood purification techniques might be a good choice in their treatment. In this study we aimed to investigate the role of cytokine removal in COVID-19 patients managed in ICUs. Methods: For this case-control study we have investigated the role of the cytokine removal by means of two resin membranes (HA330 and Mediasorb) in COVID-19 patients managed in ICUs. Particularly, we investigated the overtime variation in clinical severity scores, laboratory variables, and effects on hospital and ICU stay and mortality. Results: Seventy-two patients have been evaluated, of which half constituted Cytokine Filtration (CF) Group, and other half the Case-Control (CC) Group. Mortality was 55.6% and 50% in CF and CC groups, respectively. In the CF Group, there was decrease in C-reactive protein (CRP) and fibrinogen levels measured at the end of cytokine adsorption; lymphocyte count and ratio were increased, whereas neutrophile ratio was decreased. There were no differences between the groups regarding other laboratory variables, SOFA scores and vasopressor uses. Conclusions: We have demonstrated decrease in CRP, fibrinogen and increase in lymphocyte count in the patients having cytokine adsorption, but there was no clinical reflection of these benefits, and no decrease in mortality as well. Even though there is physio-pathologic rationale to use cytokine adsorption techniques for immunomodulation in critically ill COVID-19 patients, it is early to make strong suggestions about their benefits.
dc.identifier.citationAbdullayev R., Gül F., Bilgili B., Seven S., Cinel I., "Cytokine Adsorption in Critically Ill COVID-19 Patients, a Case-Control Study", JOURNAL OF INTENSIVE CARE MEDICINE, cilt.37, sa.9, ss.1223-1228, 2022
dc.identifier.doi10.1177/08850666221085185
dc.identifier.endpage1228
dc.identifier.issn0885-0666
dc.identifier.issue9
dc.identifier.startpage1223
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/7f808366-c6f1-4f4e-ae56-5ccbc5651f66/file
dc.identifier.urihttps://hdl.handle.net/11424/287820
dc.identifier.volume37
dc.language.isoeng
dc.relation.ispartofJOURNAL OF INTENSIVE CARE MEDICINE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectYoğun Bakım
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectIntensive Care
dc.subjectYOĞUN BAKIM
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectCRITICAL CARE MEDICINE
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectCritical Care and Intensive Care Medicine
dc.subjectadsorption
dc.subjectblood purification
dc.subjectCOVID-19
dc.subjectcytokine filtration
dc.subjectintensive care unit
dc.subjectBLOOD PURIFICATION
dc.subjectHEMOPERFUSION
dc.subjectINJURY
dc.subjectSTORM
dc.titleCytokine Adsorption in Critically Ill COVID-19 Patients, a Case-Control Study
dc.typearticle
dspace.entity.typePublication
local.avesis.id7f808366-c6f1-4f4e-ae56-5ccbc5651f66
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationcd36c0de-bb06-48f2-89c0-cfdf8edc5d7a
relation.isAuthorOfPublicationc1a337e4-d6be-4d98-821d-1b76c3b3f287
relation.isAuthorOfPublication09623f32-1506-4c73-9168-b8ec0e880ab0
relation.isAuthorOfPublication202e7185-bae9-46db-9cdd-f2f0881870aa
relation.isAuthorOfPublication907a6efd-2877-4832-b6a2-d87a28e52165
relation.isAuthorOfPublication.latestForDiscoverycd36c0de-bb06-48f2-89c0-cfdf8edc5d7a

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
file.pdf
Size:
542.01 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs