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Protective Effects of Lycopene on Cerulein-Induced Experimental Acute Pancreatitis in Rats

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dc.contributor.authorDULUNDU, ENDER
dc.contributor.authorsOzkan, Erkan; Akyuz, Cebrail; Dulundu, Ender; Topaloglu, Umit; Sehirli, Ahmet Ozer; Ercan, Feriha; Sener, Goksel
dc.date.accessioned2022-03-12T18:06:16Z
dc.date.available2022-03-12T18:06:16Z
dc.date.issued2012
dc.description.abstractBackground. The purpose of our study was to evaluate the protective effect of the strong antioxidant and anti-inflammatory agent, lycopene, on oxidative stress in a rat model of cerulein-induced acute edematous pancreatitis. Methods. Sprague-Dawley rats were pretreated with lycopene (50 mg/kg, i.p.) or saline 15 min before cerulein was given 20 mu g/kg (i.p.) at 1-h intervals within 4 h. Twelve hours after cerulein or saline injections, the animals were killed by decapitation. Blood samples were collected to analyze amylase, lipase, and proinflammatory cytokines (TNF-alpha and IL-1 beta). Pancreatic tissues were taken for the determination of tissue glutathione (GSH) and malondialdehyde (MDA) levels, Na+/K+-ATPase, and myeloperoxidase (MPO) activities. Tissue samples were also examined histologically. Results. Acute pancreatitis caused significant decrease in tissue GSH levels and Na+/K+-ATPase activity, while pancreatic MDA levels and MPO activity were increased. Furthermore, TNF-alpha, IL-1 beta, and amylase lipase levels were also significantly increased. On the other hand, lycopene pretreatment reserved all these biochemical indices as well as histopathologic alterations that were induced by cerulein. Conclusions. According to the results, lycopene protects the pancreatic tissues from oxidative damage induced by cerulein, and this effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation. These results suggest that high dietary intake of tomatoes may have protective effects against acute pancreatitis. (C) 2012 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jss.2011.09.005
dc.identifier.eissn1095-8673
dc.identifier.issn0022-4804
dc.identifier.pubmed22079843
dc.identifier.urihttps://hdl.handle.net/11424/230870
dc.identifier.wosWOS:000305210100042
dc.language.isoeng
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofJOURNAL OF SURGICAL RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectpancreatitis
dc.subjectlycopene
dc.subjectoxidative damage
dc.subjectcytokines
dc.subjectOXIDATIVE STRESS
dc.subjectULTRASTRUCTURAL CLUES
dc.subjectFREE-RADICALS
dc.subjectINFLAMMATION
dc.subjectDAMAGE
dc.subjectMECHANISMS
dc.subjectGLUTATHIONE
dc.subjectACTIVATION
dc.subjectMODEL
dc.subjectBIOMARKERS
dc.titleProtective Effects of Lycopene on Cerulein-Induced Experimental Acute Pancreatitis in Rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id4ca67637-ac4a-4811-b6b3-d4ac38d32a42
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages7
oaire.citation.endPage238
oaire.citation.issue1
oaire.citation.startPage232
oaire.citation.titleJOURNAL OF SURGICAL RESEARCH
oaire.citation.volume176
relation.isAuthorOfPublicationedcd2255-94d5-4f56-b0c8-1385c55279b0
relation.isAuthorOfPublication.latestForDiscoveryedcd2255-94d5-4f56-b0c8-1385c55279b0

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