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High intensity interval training protects from Post Traumatic Stress Disorder induced cognitive impairment

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dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorsKoyuncuoglu, Turkan; Sevim, Hacer; Cetrez, Nursen; Meral, Zeynep; Gonenc, Berfin; Dertsiz, Ekin Kuntsal; Akakin, Dilek; Yuksel, Meral; Cakir, Ozgur Kasimay
dc.date.accessioned2022-03-12T22:55:16Z
dc.date.available2022-03-12T22:55:16Z
dc.date.issued2021
dc.description.abstractThis study aimed to show the possible protective effects of high intensity interval training (HIIT) in PTSD-induced rats and probable underlying mechanisms. Female rats (n = 44) were separated as; Sedentary (SED), moderate intensity continuous training (MICT), HIIT groups. Then the groups were divided into subgroups according to PTSD induction (n = 6-8/group). Exercise groups performed HIIT or MICT for 6 weeks. On the fifth week, PTSD was induced by single prolonged stress protocol. Cognitive functions were evaluated by object recognition, anxiety levels by hole-board and elevated plus maze, and fear conditioning by passive avoidance tests. Following decapitation, malondialdehyde (MDA), glutathione (GSH), luminol and lucigenin chemiluminescence levels, and myeloperoxidase (MPO), superoxide dismutase (SOD) and catalase (CAT) activities were measured, and histopathological damage was evaluated. The data was analyzed by one-way ANOVA. Cognitive decline and aggravated anxiety levels in SED + PTSD group were improved in both PTSD-induced exercise groups (p < 0.05-0.001). The increased chemiluminescence levels, MPO activity and histological damage were depressed in both PTSD-induced exercise groups (p < 0.05-0.001). The risen MDA levels in SED + PTSD group were suppressed only in HIIT + PTSD group (p < 0.01-0.001). The decreased GSH levels were increased by MICT (p < 0.05-0.001), and CAT and SOD activities were improved via HIIT < 0.05). Compared to SED group, latency was decreased in SED + PTSD < 0.05-0.01) group. Neuronal damage scores were alleviated in both PTSD-induced exercise groups (p < 0.001). PTSD-induced memory decline was protected by both of the exercise models however more effectively by HIIT via decreasing oxidative stress, anxiety levels and by improving antioxidant capacity as a protective system for neuronal damage.
dc.identifier.doi10.1016/j.bbr.2020.112923
dc.identifier.eissn1872-7549
dc.identifier.issn0166-4328
dc.identifier.pubmed32976860
dc.identifier.urihttps://hdl.handle.net/11424/236698
dc.identifier.wosWOS:000587813500008
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofBEHAVIOURAL BRAIN RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHigh intensity interval training (HIIT)
dc.subjectModerate intensity continuous training (MICT)
dc.subjectPost Traumatic Stress Disorder (PTSD)
dc.subjectCognitive function
dc.subjectOxidative stress
dc.subjectExercise
dc.subjectRAT MODEL
dc.subjectSUPEROXIDE-DISMUTASE
dc.subjectAEROBIC EXERCISE
dc.subjectOXIDATIVE STRESS
dc.subjectANTIOXIDANT
dc.subjectMEMORY
dc.subjectANXIETY
dc.subjectPTSD
dc.subjectPERFORMANCE
dc.subjectVALIDATION
dc.titleHigh intensity interval training protects from Post Traumatic Stress Disorder induced cognitive impairment
dc.typearticle
dspace.entity.typePublication
local.avesis.id032ae216-9289-47b2-80eb-b26b3152b8ec
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber112923
local.journal.numberofpages11
oaire.citation.titleBEHAVIOURAL BRAIN RESEARCH
oaire.citation.volume397
relation.isAuthorOfPublicationc97c0ebf-ffce-4b27-a933-941a53767b0d
relation.isAuthorOfPublication.latestForDiscoveryc97c0ebf-ffce-4b27-a933-941a53767b0d

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