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Biological activities of aerial parts extracts of endemic Tanacetum argenteum subsp. argenteum

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsSen, Ali; Ozakpinar, Ozlem Bingol; Tan, Seher Birteksoz; Kultur, Sukran; Uras, Fikriye; Bitis, Leyla
dc.date.accessioned2022-03-14T08:28:01Z
dc.date.available2022-03-14T08:28:01Z
dc.date.issued2017-04-01
dc.description.abstractThe objective of the present study was to investigate the antimicrobial and anti-proliferative activities of n-hexane, chloroform, methanol and aqueous methanol extracts obtained from Tanacetum argenteum subsp. argenteum aerial parts. Anti-proliferative activity was tested in vitro against four human cancer cell lines (A549: lung adenocarcinoma, Hela; cervix adenocarcinoma, HT-29: colon adenocarcinoma, MCF-7; breast adenocarcinoma) using MTT assay. Antimicrobial activity was assessed by micro-broth dilution technique against Staphylococcus aureus ATCC 29213, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 27853, Proteus mirabilis ATCC 14153, and Candida albicans ATCC 10231. Hexane extract inhibited proliferation of HT-29 and MCF-7 by 75 and 74% while chloroform extract against the same cancer cell lines displayed inhibition of 89 and 73% at the concentration of 30 mu g/mL, respectively. Also, chloroform extract at the same concentration showed significant anti-proliferative activity against A-549 and HeLa with inhibition values of 75% and 62%. Chloroform extract exhibited moderate antibacterial activity against Staphylococcus aureus and S. epidermidis with the MIC values of 625 mu g/mL. Methanol and aqueous methanol extracts showed weak antimicrobial activity against Staphylococcus epidermidis and Candida albicans with MIC values of 1250 mu g/mL. The results showed that n-hexane and chloroform extracts have significant anticancer activity against cancer cell lines used in this study.
dc.identifier.doi10.12991/marupj.300357
dc.identifier.issn1309-0801
dc.identifier.urihttps://hdl.handle.net/11424/241833
dc.identifier.wosWOS:000411289700011
dc.language.isoeng
dc.publisherMARMARA UNIV, FAC PHARMACY
dc.relation.ispartofMARMARA PHARMACEUTICAL JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAsteraceae
dc.subjectantimicrobial activity
dc.subjectanti-proliferative activity
dc.subjectn-hexane extract
dc.subjectchloroform extract
dc.subjectANTIOXIDANT ACTIVITIES
dc.subjectANTIMICROBIAL ACTIVITY
dc.subjectESSENTIAL OIL
dc.subjectFLABELLIFOLIUM
dc.subjectFLAVONOIDS
dc.subjectPLANTS
dc.subjectCELLS
dc.titleBiological activities of aerial parts extracts of endemic Tanacetum argenteum subsp. argenteum
dc.typearticle
dspace.entity.typePublication
local.avesis.id060fa800-a1f0-40af-8931-59850c242936
local.import.packageSS16
local.indexed.atWOS
local.indexed.atTRDIZIN
local.journal.numberofpages5
oaire.citation.endPage290
oaire.citation.issue2
oaire.citation.startPage286
oaire.citation.titleMARMARA PHARMACEUTICAL JOURNAL
oaire.citation.volume21
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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