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Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsBozaykut, Perinur; Sahin, Ali; Karademir, Betul; Ozer, Nesrin Kartal
dc.date.accessioned2022-03-12T20:27:02Z
dc.date.available2022-03-12T20:27:02Z
dc.date.issued2016
dc.description.abstractNonalcoholic steatohepatitis (NASH) is considered to be a common health problem since the incidence of nonalcoholic fatty liver disease (NAFLD) has increased in recent years. Disturbed hepatic cholesterol homeostasis and free cholesterol accumulation in liver results in increased oxidative stress leading to the endoplasmic reticulum (ER) stress. Activated ER stress maintains protein homeostasis however, delayed or inadequate ER stress responses may induce fat accumulation, insulin resistance, inflammation, apoptosis, and autophagy, all of which increase with age and play crucial roles in the pathogenesis of NASH. In aging research, there is a growing interest for the role of ER stress in the progression of NASH since aging seems to favor NAFLD according to its pathogenesis. On the other hand, specific microRNAs (miRNAs) expression profiles are strongly related with ER stress as well as NASH progresses. This review highlights molecular mechanisms related to ER stress in the pathogenesis of NASH and miRNAs for the progression and treatment of the disease. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.mad.2016.07.001
dc.identifier.eissn1872-6216
dc.identifier.issn0047-6374
dc.identifier.pubmed27393639
dc.identifier.urihttps://hdl.handle.net/11424/233613
dc.identifier.wosWOS:000383303000003
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofMECHANISMS OF AGEING AND DEVELOPMENT
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNonalcoholic steatohepatitis
dc.subjectHypercholesterolemia
dc.subjectEndoplasmic reticulum stress
dc.subjectUnfolded protein response
dc.subjectMicroRNAs
dc.subjectUNFOLDED PROTEIN RESPONSE
dc.subjectFATTY LIVER-DISEASE
dc.subjectNF-KAPPA-B
dc.subjectPERK-DEPENDENT REGULATION
dc.subjectC/EBP HOMOLOGOUS PROTEIN
dc.subjectTNF-INDUCED APOPTOSIS
dc.subjectCOENZYME-A REDUCTASE
dc.subjectER STRESS
dc.subjectOXIDATIVE STRESS
dc.subjectLIPID-METABOLISM
dc.titleEndoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis
dc.typearticle
dspace.entity.typePublication
local.avesis.id8e07a321-2a31-4634-b2ad-2d6610b1a247
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages13
local.journal.quartileQ2
oaire.citation.endPage29
oaire.citation.startPage17
oaire.citation.titleMECHANISMS OF AGEING AND DEVELOPMENT
oaire.citation.volume157
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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