Publication:
The effects of Nigella sativa against oxidative injury in a rat model of subarachnoid hemorrhage

Simple item page
dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsErsahin, Mehmet; Toklu, Hale Z.; Akakin, Dilek; Yuksel, Meral; Yegen, Berrak C.; Sener, Goksel
dc.date.accessioned2022-03-12T17:52:07Z
dc.date.available2022-03-12T17:52:07Z
dc.date.issued2011
dc.description.abstractThe aim of the study was to investigate the putative neuroprotective effect of Nigella sativa oil (NSO) treatment against subarachnoid hemorrhage (SAH) in rats. To induce SAH, rats were injected with 0.3 ml blood into their cisterna magna. Male Wistar albino rats were divided as control, vehicle-treated SAH, and NSO-treated (0.2 ml/kg, intraperitoneally) SAH groups. Forty-eight hours after SAH induction, neurological examination scores were recorded and the rats were decapitated. Brain tissue samples were taken for blood brain barrier permeability, brain water content, or determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO), and Na+-K+-ATPase activities. On the second day of SAH induction, neurological examination scores were increased in SAH groups, while SAH caused significant decreases in brain GSH content and Na+-K+-ATPase activity, which were accompanied with significant increases in MDA levels and MPO activity. The histological observation showed vasospasm of the basillary artery. On the other hand, NSO treatment markedly improved the neurological scores while all oxidant responses were prevented, implicating that NSO treatment may be of therapeutic use in preventing oxidative stress due to SAH.
dc.identifier.doi10.1007/s00701-010-0853-9
dc.identifier.eissn0942-0940
dc.identifier.issn0001-6268
dc.identifier.pubmed21072672
dc.identifier.urihttps://hdl.handle.net/11424/230369
dc.identifier.wosWOS:000286661100016
dc.language.isoeng
dc.publisherSPRINGER WIEN
dc.relation.ispartofACTA NEUROCHIRURGICA
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSubarachnoid hemorrhage
dc.subjectNigella sativa
dc.subjectOxidative stress
dc.subjectCerebral ischemia
dc.subjectCerebral vasospasm
dc.subjectISCHEMIA-REPERFUSION INJURY
dc.subjectSPINAL-CORD-INJURY
dc.subjectALPHA-LIPOIC ACID
dc.subjectCEREBRAL VASOSPASM
dc.subjectBRAIN-INJURY
dc.subjectMAJOR CONSTITUENT
dc.subjectIN-VITRO
dc.subjectTHYMOQUINONE
dc.subjectDAMAGE
dc.subjectAPOPTOSIS
dc.titleThe effects of Nigella sativa against oxidative injury in a rat model of subarachnoid hemorrhage
dc.typearticle
dspace.entity.typePublication
local.avesis.id632ad5b8-fa1d-4ee2-860c-8e614362e8e0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
oaire.citation.endPage341
oaire.citation.issue2
oaire.citation.startPage333
oaire.citation.titleACTA NEUROCHIRURGICA
oaire.citation.volume153
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

Files

Collections

Research Outputs