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Evaluation of the protective effect of Myrtus communis in scopolamine induced Alzheimer model through cholinergic receptors

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsAykac, Asli; Ozbeyli, Dilek; Uncu, Murat; Ertas, Busra; Kilinc, Olca; Sen, Ali; Orun, Oya; Sener, Goksel
dc.date.accessioned2022-03-12T22:38:19Z
dc.date.available2022-03-12T22:38:19Z
dc.date.issued2019
dc.description.abstractAlzheimer's disease is a progressive neurodegenerative disorder causing common health problem with increasing age. Evidences show that the key symptoms of AD are mainly caused by cholinergic system dysfunction which has a role in cognitive disorders. Cholinergic pathways especially muscarinic receptors like M-1 subtype also have a major role in learning, memory, cognitive functions and emotional state. There is no available permanent treatment currently to cure AD or to change its progression. This study was designed to investigate the factors that play important role in pathogenesis of AD and to compare the effects of Galantamine treatment with effects of Myrtus communis treatment. The expression level of M-1, ACh, BDNF; AChE activity, GSH level, MDA and MPO activity and AChE gene expression were investigated in scopolamine-induced rat model. Results showed that, administration of MC significantly improves the SCOP-induced reduction of latency and object recognition time; increasing BDNF, M-1 and ACh receptor expression levels in the different brain regions. Additionally, MC showed an increased in AChE by enhancing GSH activity and reducing MDA level and MPO activity. In conclusion MC considered as a possible novel therapeutic approach that can be a valuable alternative way in the prevention and treatment of AD.
dc.identifier.doi10.1016/j.gene.2018.12.007
dc.identifier.eissn1879-0038
dc.identifier.issn0378-1119
dc.identifier.pubmed30553998
dc.identifier.urihttps://hdl.handle.net/11424/235590
dc.identifier.wosWOS:000459216900024
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofGENE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMyrtus communis
dc.subjectScopolamine
dc.subjectMuscarinic reseptor M-1
dc.subjectBDNF
dc.subjectAChE
dc.subjectINDUCED MEMORY IMPAIRMENT
dc.subjectOXIDATIVE STRESS
dc.subjectACETYLCHOLINESTERASE INHIBITION
dc.subjectRATS
dc.subjectNEUROINFLAMMATION
dc.subjectDISEASE
dc.subjectBRAIN
dc.subjectL.
dc.subjectINFLAMMATION
dc.subjectRECOGNITION
dc.titleEvaluation of the protective effect of Myrtus communis in scopolamine induced Alzheimer model through cholinergic receptors
dc.typearticle
dspace.entity.typePublication
local.avesis.id502bedc0-dde4-463a-94b3-57c0df9a530d
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ2
oaire.citation.endPage201
oaire.citation.startPage194
oaire.citation.titleGENE
oaire.citation.volume689
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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