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Single-Walled (Magnetic) Carbon Nanotubes in a Pectin Matrix in the Design of an Allantoin Delivery System

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dc.contributor.authorBATIREL, SAİME
dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsGüner Yılmaz Ö. Z., Yılmaz A., Bozoglu S., Yavuz N., BATIREL S., ŞAHİN A., Güner F. S.
dc.date.accessioned2024-03-15T07:03:35Z
dc.date.available2024-03-15T07:03:35Z
dc.date.issued2023-01-01
dc.description.abstractSingle-walled carbon nanotubes (SWCNTs) outperform other materials due to their high conductivity, large specific surface area, and chemical resistance. They have numerous biomedical applications, including the magnetization of the SWCNT (mSWCNT). The drug loading and release properties of see-through pectin hydrogels doped with SWCNTs and mSWCNTs were evaluated in this study. The active molecule in the hydrogel structure is allantoin, and calcium chloride serves as a cross-linker. In addition to mixing, absorption, and swelling techniques, drug loading into carbon nanotubes was also been studied. To characterize the films, differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), Fourier transform infrared (FTIR) spectroscopy, surface contact angle measurements, and opacity analysis were carried out. Apart from these, a rheological analysis was also carried out to examine the flow properties of the hydrogels. The study was also expanded to include N-(9-fluorenyl methoxycarbonyl)glycine-coated SWCNTs and mSWCNTs as additives to evaluate the efficiency of the drug-loading approach. Although the CNT additive was used at a 1:1000 weight ratio, it had a significant impact on the hydrogel properties. This effect, which was first observed in the thermal properties, was confirmed in rheological analyses by increasing solution viscosity. Additionally, rheological analysis and drug release profiles show that the type of additive causes a change in the matrix structure. According to TGA findings, even though SWCNTs and mSWCNTs were not coated more than 5%, the coating had a significant effect on drug release control. In addition to all findings, cell viability tests revealed that hydrogels with various additives could be used for visual wound monitoring, hyperthermia treatment, and allantoin release in wound treatment applications.
dc.identifier.citationGüner Yılmaz Ö. Z., Yılmaz A., Bozoglu S., Yavuz N., BATIREL S., ŞAHİN A., Güner F. S., "Single-Walled (Magnetic) Carbon Nanotubes in a Pectin Matrix in the Design of an Allantoin Delivery System", ACS Omega, 2023
dc.identifier.doi10.1021/acsomega.3c03619
dc.identifier.issn2470-1343
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85186070306&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/296479
dc.language.isoeng
dc.relation.ispartofACS Omega
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya Mühendisliği ve Teknolojisi
dc.subjectKimya
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectChemical Engineering and Technology
dc.subjectChemistry
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectMühendislik
dc.subjectMÜHENDİSLİK, KİMYASAL
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectENGINEERING
dc.subjectCHEMISTRY
dc.subjectENGINEERING, CHEMICAL
dc.subjectGenel Kimya
dc.subjectFizik Bilimleri
dc.subjectGenel Kimya Mühendisliği
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.subjectGeneral Chemical Engineering
dc.titleSingle-Walled (Magnetic) Carbon Nanotubes in a Pectin Matrix in the Design of an Allantoin Delivery System
dc.typearticle
dspace.entity.typePublication
local.avesis.id63a8d005-0dd1-4230-bfab-11f1a0e42366
local.indexed.atSCOPUS
relation.isAuthorOfPublication819f23bf-7f20-4c27-95c0-15d1a199b19d
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscovery819f23bf-7f20-4c27-95c0-15d1a199b19d

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