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Betulinic Acid Protects against Ischemia/Reperfusion-induced Renal Damage and Inhibits Leukocyte Apoptosis

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsEksioglu-Demiralp, Emel; Kardas, E. Riza; Ozgul, Seckin; Yagci, Tayfur; Bilgin, Hueseyin; Sehirli, Oezer; Ercan, Feriha; Sener, Goeksel
dc.date.accessioned2022-03-14T09:16:59Z
dc.date.available2022-03-14T09:16:59Z
dc.date.issued2010-03
dc.description.abstractThe possible protective effect of betulinic acid on renal ischemia/reperfusion (I/R) injury was studied. Wistar Albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 6 h of reperfusion. Betulinic acid (250 mg/kg, i.p.) or saline was administered at 30 min prior to ischemia and immediately before the reperfusion. Creatinine, blood urea nitrogen (BUN), lactate dehydrogenase (LDH) and TNF-alpha as well as the oxidative burst of neutrophil and leukocyte apoptosis were assayed in blood samples. Malondialdehyde (MDA), glutathione (GSH) levels, Na+, K+-ATPase and myeloperoxidase (MPO) activities were determined in kidney tissue which was also analysed microscopically. I/R caused significant increases in blood creatinine, BUN, LDH and TNF-alpha. In the kidney samples of the I/R group, MDA levels and MPO activity were increased significantly, however, GSH levels and Na+, K+-ATPase activity were decreased. Betulinic acid ameliorated the oxidative burst response to both formyl-methionyl-leucyl-phenylalanine (fMLP) and phorbol 12-myristate 13-acetate (PMA) stimuli, normalized the apoptotic response and most of the biochemical indices as well as histopathological alterations induced by I/R. In conclusion, these data suggest that betulinic acid attenuates I/R-induced oxidant responses, improved microscopic damage and renal function by regulating apoptotic function of leukocytes and inhibiting neutrophil infiltration. Copyright (C) 2009 John Wiley & Sons, Ltd.
dc.identifier.doi10.1002/ptr.2929
dc.identifier.eissn1099-1573
dc.identifier.issn0951-418X
dc.identifier.pubmed19610040
dc.identifier.urihttps://hdl.handle.net/11424/242903
dc.identifier.wosWOS:000275434900002
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofPHYTOTHERAPY RESEARCH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbetulinic acid
dc.subjectischemia/reperfusion
dc.subjectkidney
dc.subjectapoptosis
dc.subjectlipid peroxidation
dc.subjectISCHEMIA-REPERFUSION INJURY
dc.subjectRAT-KIDNEY
dc.subjectTISSUE-INJURY
dc.subjectFREE-RADICALS
dc.subjectFAILURE
dc.subjectMYELOPEROXIDASE
dc.subjectTRITERPENOIDS
dc.subjectMECHANISMS
dc.subjectDISCOVERY
dc.titleBetulinic Acid Protects against Ischemia/Reperfusion-induced Renal Damage and Inhibits Leukocyte Apoptosis
dc.typearticle
dspace.entity.typePublication
local.avesis.id042ce1a6-06a9-45f0-8054-dab74c6fb282
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage332
oaire.citation.issue3
oaire.citation.startPage325
oaire.citation.titlePHYTOTHERAPY RESEARCH
oaire.citation.volume24
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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