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A Critical Appraisal of the Effect of Gonadotropin-Releasing Hormon Analog Treatment on Adult Height of Girls with Central Precocious Puberty

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dc.contributor.authorsBereket, Abdullah
dc.date.accessioned2022-03-10T11:40:33Z
dc.date.available2022-03-10T11:40:33Z
dc.date.issued2018-01-15
dc.description.abstractCentral precocious puberty (CPP) is a diagnosis that pediatric endocrinologists worldwide increasingly make in girls of age 6-8 years and is mostly idiopathic. Part of the reason for increasing referral and diagnosis is the perception among the doctors as well as the patients that treatment of CPP with long-acting gonadotropin-releasing hormon analogues (GnRHa) promote height of the child. Although, the timing and the tempo of puberty does influence statural growth and achieved adult height, the extent of this effect is variable depending on several factors and is modest in most cases. Studies investigating GnRHa treatment in girls with idiopathic CPP demonstrate that treatment is able to restore adult height compromised by precocious puberty. However, reports on untreated girls with precocious puberty demonstrate that some of these girls achieve their target height without treatment as well, thus, blurring the net effect of GnRHa treatment on height in girls with CPP. Clinical studies on treatment of girls with idiopathic CPP on adult stature suffers from the solid evidence-base due mainly to the lack of well-designed randomized controlled studies and our insufficiencies of predicting adult height of a child with narrow precision. This is particularly true for girls in whom age of pubertal onset is close to physiological age of puberty, which are the majority of cases treated with GnRHa nowadays. Heterogeneous nature of pubertal tempo (progressive vs. nonprogressive) leading to different height outcomes also complicates the interpretation of the results in both treated and untreated cases. This review will attemp to summarize and critically appraise available data in the field.
dc.identifier.doi10.4274/jcrpe.2017.S004
dc.identifier.eissn1308-5735
dc.identifier.issn1308-5727
dc.identifier.pubmed29280737
dc.identifier.urihttps://hdl.handle.net/11424/220012
dc.identifier.wosWOS:000422711600005
dc.language.isoeng
dc.publisherGALENOS YAYINCILIK
dc.relation.ispartofJOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCentral precocious puberty
dc.subjectgonadotropin-releasing hormon analogues
dc.subjecttreatment
dc.subjectfinal height
dc.subjectadult height
dc.subjectgrowth
dc.subjecttriptoreli
dc.subjectleuprolide
dc.subjectLONG-TERM TREATMENT
dc.subjectCOMBINED GROWTH-HORMONE
dc.subjectFINAL HEIGHT
dc.subjectPREMATURE THELARCHE
dc.subjectGNRH ANALOG
dc.subjectEARLY DIFFERENTIATION
dc.subjectSUPPRESSIVE THERAPY
dc.subjectAGONIST TREATMENT
dc.subjectADOPTED GIRLS
dc.subjectFOLLOW-UP
dc.titleA Critical Appraisal of the Effect of Gonadotropin-Releasing Hormon Analog Treatment on Adult Height of Girls with Central Precocious Puberty
dc.typereview
dspace.entity.typePublication
local.avesis.id4ead6252-8231-4c22-beeb-056c82b74fbb
local.import.packageSS4
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.indexed.atTRDIZIN
local.journal.numberofpages16
local.journal.quartileQ3
oaire.citation.endPage48
oaire.citation.startPage33
oaire.citation.titleJOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
oaire.citation.volume9

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