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Serum osteoprotegerin levels, endothelial function and carotid intima-media thickness in type 2 diabetic patients

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dc.contributor.authorYAVUZ, DİLEK
dc.contributor.authorsGunes, Mutlu; Temizkan, Sule; Apaydin, Tugce; Ilgin, Can; Haklar, Goncagul; Yavuz, Dilek Gogas
dc.date.accessioned2022-03-12T22:55:41Z
dc.date.available2022-03-12T22:55:41Z
dc.date.issued2021
dc.description.abstractObjectives: Osteoprotegerin (OPG), a well-known protein that inhibits osteoclast formation and activity, might also be a potential marker for identifying patients with high cardiovascular risk. This study aimed to compare OPG levels, FMD, and CIMT measurements in subjects with vs. without diabetes and investigate the association of serum osteoprotegerin level with the early atherosclerotic markers, endothelial function, and carotid intimamedia thickness (CIMT) in patients with type 2 diabetes mellitus (DM2). Methods: Forty-nine patients with DM2 (F/M: 26/23, 49.3 +/- 10.0 years) and 45 healthy volunteers (F/M: 26/19, 48.3 +/- 7.5 years) were included in this cross-sectional study. Serum OPG levels were measured by solid-phase enzyme-linked immunosorbent assay (ELISA). Fasting plasma glucose (FPG) and HbA1c levels were measured. CIMT was measured by B-mode ultrasound, and endothelial function was evaluated via flow-mediated dilation (FMD) of the brachial artery with Doppler ultrasonography. Results: Serum OPG levels were significantly higher in patients with DM2 (617.0 +/- 111.0 pg/mL) compared to controls (481.0 +/- 96.0 pg/mL, p < 0.001). While CIMT in diabetic patients (0.65 + 0.13 mm) was higher than controls (0.54 +/- 0.10 mm, p = 0.009), FMD measurement was lower in DM2 group (4.2% +/- 3.1 mm vs. 7.6% +/- 4.1 mm, p = 0.01). Univariate analysis showed that OPG was associated with the presence of diabetes (OR: 6.999, p = 0.001, R-2: 15.1%) and hypertension (OR = 6.925, p = 0.001, R-2: 13.2%). There was no relationship between OPG levels and CIMT or FMD. Conclusion: Osteoprotegerin and CIMT levels were increased, and FMD measurements were decreased in patients with DM2. No association between CIMT, FMD, and OPG measurements was observed. The presence of DM and hypertension were associated with circulating OPG levels.
dc.identifier.doi10.1016/j.jdiacomp.2021.108073
dc.identifier.eissn1873-460X
dc.identifier.issn1056-8727
dc.identifier.pubmed34635402
dc.identifier.urihttps://hdl.handle.net/11424/236804
dc.identifier.wosWOS:000720776900001
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJOURNAL OF DIABETES AND ITS COMPLICATIONS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectType 2 diabetes mellitus
dc.subjectOsteoprotegerin
dc.subjectFlow-mediated dilation
dc.subjectEndothelial function
dc.subjectCarotid intima-media thickness
dc.subjectVASCULAR CALCIFICATION
dc.subjectPLASMA OSTEOPROTEGERIN
dc.subjectMYOCARDIAL-INFARCTION
dc.subjectPREDICTIVE-VALUE
dc.subjectARTERY-DISEASE
dc.subjectTASK-FORCE
dc.subjectATHEROSCLEROSIS
dc.subjectDYSFUNCTION
dc.subjectRISK
dc.subjectVASODILATION
dc.titleSerum osteoprotegerin levels, endothelial function and carotid intima-media thickness in type 2 diabetic patients
dc.typearticle
dspace.entity.typePublication
local.avesis.idf0d5aa10-c9ab-4c58-9ffd-6fd045809877
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber108073
local.journal.numberofpages5
oaire.citation.issue12
oaire.citation.titleJOURNAL OF DIABETES AND ITS COMPLICATIONS
oaire.citation.volume35
relation.isAuthorOfPublication26174ec5-7dca-4038-a7fe-9a43f236fd15
relation.isAuthorOfPublication.latestForDiscovery26174ec5-7dca-4038-a7fe-9a43f236fd15

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