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Evaluation of burst release and sustained release of pioglitazone-loaded fibrous mats on diabetic wound healing: an in vitro and in vivo comparison study

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dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorsCam, Muhammet Emin; Yildiz, Sila; Alenezi, Hussain; Cesur, Sumeyye; Ozcan, Gul Sinemcan; Erdemir, Gokce; Edirisinghe, Ursula; Akakin, Dilek; Kuruca, Durdane Serap; Kabasakal, Levent; Gunduz, Oguzhan; Edirisinghe, Mohan
dc.date.accessioned2022-03-14T09:24:35Z
dc.date.available2022-03-14T09:24:35Z
dc.date.issued2020-01
dc.description.abstractIn order to provide more effective treatment strategies for the rapid healing of diabetic wounds, novel therapeutic approaches need to be developed. The therapeutic potential of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist pioglitazone hydrochloride (PHR) in two different release kinetic scenarios, burst release and sustained release, was investigated and compared with in vitro and in vivo tests as potential wound healing dressings. PHR-loaded fibrous mats were successfully fabricated using polyvinyl-pyrrolidone and polycaprolactone by scalable pressurized gyration. The results indicated that PHR-loaded fibrous mats expedited diabetic wound healing in type-1 diabetic rats and did not show any cytotoxic effect on NIH/3T3 (mouse embryo fibroblast) cells, albeit with different release kinetics and efficacies. The wound healing effects of fibrous mats are presented with histological and biochemical evaluations. PHR-loaded fibrous mats improved neutrophil infiltration, oedema, and inflammation and increased epidermal regeneration and fibroblast proliferation, but the formation of hair follicles and completely improved oedema were observed only in the sustained release form. Thus, topical administration of PPAR-gamma agonist in sustained release form has high potential for the treatment of diabetic wounds in inflammatory and proliferative phases of healing with high bioavailability and fewer systemic side effects.
dc.identifier.doi10.1098/rsif.2019.0712
dc.identifier.eissn1742-5662
dc.identifier.issn1742-5689
dc.identifier.pubmed31964272
dc.identifier.urihttps://hdl.handle.net/11424/243083
dc.identifier.wosWOS:000538369800006
dc.language.isoeng
dc.publisherROYAL SOC
dc.relation.ispartofJOURNAL OF THE ROYAL SOCIETY INTERFACE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectburst release
dc.subjectsustained release
dc.subjectdrug delivery
dc.subjectfibres
dc.subjectdiabetic wound healing
dc.subjectpioglitazone
dc.subjectPROLIFERATOR-ACTIVATED RECEPTOR
dc.subjectGAMMA AGONIST
dc.subjectPPAR
dc.subjectDELIVERY
dc.subjectFIBROBLASTS
dc.titleEvaluation of burst release and sustained release of pioglitazone-loaded fibrous mats on diabetic wound healing: an in vitro and in vivo comparison study
dc.typearticle
dspace.entity.typePublication
local.avesis.id26533e3c-52b3-4077-8540-b7ef5d938041
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber20190712
local.journal.numberofpages12
local.journal.quartileQ2
oaire.citation.issue162
oaire.citation.titleJOURNAL OF THE ROYAL SOCIETY INTERFACE
oaire.citation.volume17
relation.isAuthorOfPublicationc97c0ebf-ffce-4b27-a933-941a53767b0d
relation.isAuthorOfPublication.latestForDiscoveryc97c0ebf-ffce-4b27-a933-941a53767b0d

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