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Alpha Lipoic Acid Alleviates Oxidative Stress and Preserves Blood Brain Permeability in Rats with Subarachnoid Hemorrhage

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsErsahin, Mehmet; Toklu, Hale Z.; Cetinel, Sule; Yuksel, Meral; Erzik, Can; Berkman, M. Zafer; Yegen, Berrak C.; Sener, Goeksel
dc.date.accessioned2022-03-12T17:48:06Z
dc.date.available2022-03-12T17:48:06Z
dc.date.issued2010
dc.description.abstractThe neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH groups, which were accompanied with significant increases in the formation of reactive oxygen species, DNA fragmentation ratios, malondialdehyde levels and myeloperoxidase activity, while significant decreases in the brain glutathione content and Na+, K+-ATPase activity were observed. On the other hand, ALA treatment reversed all these biochemical indices as well as SAH-induced histopathological alterations. Increased brain edema, impaired blood-brain-barrier permeability and neurological scores were also improved by ALA treatment. The results demonstrate that ALA exerts neuroprotective effects via the enhancement of endogenous antioxidant enzyme activity, the inhibition of neutrophil accumulation and free radical generation, suggesting a therapeutic potential in reducing secondary injury after SAH in patients.
dc.identifier.doi10.1007/s11064-009-0072-z
dc.identifier.eissn1573-6903
dc.identifier.issn0364-3190
dc.identifier.pubmed19823933
dc.identifier.urihttps://hdl.handle.net/11424/229897
dc.identifier.wosWOS:000274403600009
dc.language.isoeng
dc.publisherSPRINGER/PLENUM PUBLISHERS
dc.relation.ispartofNEUROCHEMICAL RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlpha lipoic acid
dc.subjectAntioxidant
dc.subjectCerebral vasospasm
dc.subjectSubarachnoid hemorrhage
dc.subjectLipid peroxidation
dc.subjectENDOTHELIAL DYSFUNCTION
dc.subjectRADICAL SCAVENGER
dc.subjectREACTIVE OXYGEN
dc.subjectINTRACELLULAR GLUTATHIONE
dc.subjectNA+,K+-ATPASE ACTIVITY
dc.subjectCEREBRAL VASOSPASM
dc.subjectLIPID-PEROXIDATION
dc.subjectDOUBLE-BLIND
dc.subjectCELL-DEATH
dc.subjectINJURY
dc.titleAlpha Lipoic Acid Alleviates Oxidative Stress and Preserves Blood Brain Permeability in Rats with Subarachnoid Hemorrhage
dc.typearticle
dspace.entity.typePublication
local.avesis.id4793f234-9703-4f2c-8ffd-fa5bb7dddb2a
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages11
oaire.citation.endPage428
oaire.citation.issue3
oaire.citation.startPage418
oaire.citation.titleNEUROCHEMICAL RESEARCH
oaire.citation.volume35
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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