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LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye

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dc.contributor.authorDİKPINAR, TUĞÇE
dc.contributor.authorBİTİŞ, LEYLA
dc.contributor.authorsDİKPINAR T., GÖGER F., BİTİŞ L.
dc.date.accessioned2022-12-26T17:54:09Z
dc.date.available2022-12-26T17:54:09Z
dc.date.issued2022-01-01
dc.description.abstract© 2022 Marmara University Press.In this study, in vitro ABTS, DPPH, 5-lipoxygenase, and α-glucosidase inhibitory activities of n-hexane (ASH), dichloromethane (ASD), ethyl acetate (ASE), and methanol (ASM) extracts from the aerial parts of endemic A. sieheana were assayed for the first time. The phytochemical content of ASE, the most active extract, has been first determined by LC-MS/MS. Also, the total amount of phenolic compounds of extracts were calculated. ASE demonstrated significant antioxidant activity with IC50 values of 0.096 and 0.156 mg/mL for ABTS and DPPH, respectively. ASD and ASE with IC50 values of 0.045 and 0.089 mg/mL exhibited significant anti-inflammatory activity. ASE showed moderate α-glucosidase inhibitory activity with an IC50 value of 0.774 mg/mL. Also, the total phenolic content was found to be highest in the ASE. Feruloylquinic acid, luteolin, luteolin glucoside, isorhamnetin, isovitexin, methoxyflavonoid like chrysoeriol and its glycoside derivative in the ASE were detected by LC-MS/MS. The results demonstrated that ASE had significant anti-inflammatory, antioxidant and moderate α-glucosidase inhibitory potential.
dc.identifier.citationDİKPINAR T., GÖGER F., BİTİŞ L., "LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye", Journal of Research in Pharmacy, cilt.26, sa.6, ss.1796-1804, 2022
dc.identifier.doi10.29228/jrp.270
dc.identifier.endpage1804
dc.identifier.issn2630-6344
dc.identifier.issue6
dc.identifier.startpage1796
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85142170113&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/284131
dc.identifier.volume26
dc.language.isoeng
dc.relation.ispartofJournal of Research in Pharmacy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectLife Sciences (LIFE)
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectA. sieheana
dc.subjectanti-inflammatory
dc.subjectantioxidant
dc.subjectLC-MS/MS
dc.subjectα-glucosidase
dc.titleLC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye
dc.typearticle
dspace.entity.typePublication
local.avesis.id3fcf8428-f423-4414-828e-f569392e1494
local.indexed.atSCOPUS
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relation.isAuthorOfPublication9f91deeb-ccc1-4ec8-adaa-eb62ad76b556
relation.isAuthorOfPublication.latestForDiscoverya6a2cb98-3cf2-4a51-99fd-4ec59cb04f33

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