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Composition characterization and biological activity study of achillea vermicularis extract and extract-loaded nanoparticles

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dc.contributor.authorYILMAZ SOYDAN, NACİYE TUBA
dc.contributor.authorTAŞKIN, TURGUT
dc.contributor.authorsDOĞAN M., KOÇYİĞİT Ü. M., Çetin F. N., YILMAZ SOYDAN N. T., TAŞKIN T.
dc.date.accessioned2023-01-23T08:13:02Z
dc.date.available2023-01-23T08:13:02Z
dc.date.issued2023-01-01
dc.description.abstract© 2023 International Union of Biochemistry and Molecular Biology, Inc.Antiproliferative activity of Achillea vermicularis extracts was calculated on glial (C6) and keratinocyte (HaCaT) cell lines using XTT assay. It was observed that all extracts of A. vermicularis at the determined concentration were not cytotoxic in HaCaT cell lines. The nanoparticles (NPs) of the extract with the best cytotoxic activity was prepared, and necessary characterization studies were performed. Results showed that NP containing the extract has a lower IC50 value and more cytotoxic activity in C6 cells compared to the only extract. Furthermore, the antiepileptic potentials of these substances were explored in this study. The effect of A. vermicularis extracts on the enzyme activities of carbonic anhydrase I and II isoenzymes (hCA I and hCA II) was measured using spectrophotometry to achieve this goal. A. vermicularis extracts demonstrated high inhibitory activities compared to standard inhibitor (acetazolamide, AAZ), with IC50 values in the range of 5.04–10.8 μg/ml for hCA I, and 5.40–9.22 μg/ml for hCA II. High-performance liquid chromatography diode array detector (HPLC-DAD) was used in this investigation to assess the main chemicals found in the extract and NPs. The results showed that the ethanol extract (157.636 μg/mg extract) and NPs (4.631 μg/mg extract) had a significant amount of the 8-hydroxy salvigenin component.
dc.identifier.citationDOĞAN M., KOÇYİĞİT Ü. M., Çetin F. N., YILMAZ SOYDAN N. T., TAŞKIN T., "Composition characterization and biological activity study of Achillea vermicularis extract and extract-loaded nanoparticles", Biotechnology and Applied Biochemistry, 2023
dc.identifier.doi10.1002/bab.2437
dc.identifier.issn0885-4513
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85146056915&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/285761
dc.language.isoeng
dc.relation.ispartofBiotechnology and Applied Biochemistry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiyomedikal Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectKimya
dc.subjectDiğer
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectBiomedical Engineering
dc.subjectLife Sciences
dc.subjectBiotechnology
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectChemistry
dc.subjectOther
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMühendislik
dc.subjectMikrobiyoloji
dc.subjectKİMYA, UYGULAMALI
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectMÜHENDİSLİK, BİYOMEDİKAL
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectLife Sciences (LIFE)
dc.subjectENGINEERING
dc.subjectCHEMISTRY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectMICROBIOLOGY
dc.subjectCHEMISTRY, APPLIED
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectBIOTECHNOLOGY & APPLIED MICROBIOLOGY
dc.subjectENGINEERING, BIOMEDICAL
dc.subjectBiyomühendislik
dc.subjectFizik Bilimleri
dc.subjectMoleküler Tıp
dc.subjectBiyomedikal mühendisliği
dc.subjectUygulamalı Mikrobiyoloji ve Biyoteknoloji
dc.subjectİlaç Keşfi
dc.subjectProses Kimyası ve Teknolojisi
dc.subjectBioengineering
dc.subjectPhysical Sciences
dc.subjectMolecular Medicine
dc.subjectApplied Microbiology and Biotechnology
dc.subjectDrug Discovery
dc.subjectProcess Chemistry and Technology
dc.subjectcytotoxic activity
dc.subjectencapsulation efficiency
dc.subjectenzyme inhibition
dc.titleComposition characterization and biological activity study of achillea vermicularis extract and extract-loaded nanoparticles
dc.typearticle
dspace.entity.typePublication
local.avesis.idb9a35ff8-89e3-4165-903a-ac2f778477ed
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication4a169eca-9b76-4fd5-863d-62b5fd17b23f
relation.isAuthorOfPublication265414e9-485c-42b8-903a-c467f6b49b84
relation.isAuthorOfPublication.latestForDiscovery4a169eca-9b76-4fd5-863d-62b5fd17b23f

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