Publication:
Long-term outcomes of living-related kidney donation for alport syndrome spectrum: a propensity score-matched analysis

Simple item page
dc.contributor.authorVELİOĞLU, ARZU
dc.contributor.authorsOto O. A. , Safak S., MİRİOĞLU Ş., Yelken B., VELİOĞLU A., Dirim A. B. , Guller N., YILDIZ A., ERSOY A., Turkmen A., et al.
dc.date.accessioned2022-12-02T12:59:38Z
dc.date.available2022-12-02T12:59:38Z
dc.date.issued2022-11-01
dc.description.abstractIntroduction: Data to guide the evaluation of living-related donor candidates for kidney transplant recipients with Alport syndrome (AS) spectrum are limited. We aimed to examine a cohort of living-related donors to recipients with AS and compare their outcomes with a control group to improve understanding of the clinical course and outcomes of living donation in this context. Methods: Living donors (LDs) of AS recipients and propensity score-matched control LDs without any family history of AS (control group) were followed for major cardiac events, death, post-donation estimated glomerular filtration rate (eGFR), and proteinuria. Results: There were 31 LDs (48.4% male), in whom relationship to AS recipient included mother (45.2%), father (32.3%), sibling (16.1%), grandparent (3.2%), and uncle (3.2%). Long-term outcomes over 10.0 (IQR, 3.0-15.0) years were evaluated in 25 and 25 LDs from study and control groups, respectively. During follow-up, 5 LDs (20.0%) in study group developed major cardiac event (acute coronary ischemia [n = 4] and severe congestive heart failure [n = 1]) after 5.5 (IQR, 4.5-10.3) years, whereas only 2 (8.0%) LDs in control group developed major cardiac events (p = 0.221). New-onset hypertension was higher in study group (56.0%) compared to the control group (16.0%) (p = 0.003). Three donors in study and 2 donors in control group who developed new-onset hypertension died during follow-up (p = 0.297). Major cardiac event rate was significantly higher in donors who developed hypertension after donation (0 vs. 28.0%, p < 0.001). There were no differences between study groups regarding last eGFR and proteinuria levels (p = 0.558 and p = 0.120, respectively). Discussion/Conclusion: Although the risk of kidney disease can be minimized by careful donor evaluation, our findings suggest that hypertension risk after the donation is higher than expected in related donors of recipients with AS.
dc.identifier.citationOto O. A. , Safak S., MİRİOĞLU Ş., Yelken B., VELİOĞLU A., Dirim A. B. , Guller N., YILDIZ A., ERSOY A., Turkmen A., et al., "Long-Term Outcomes of Living-Related Kidney Donation for Alport Syndrome Spectrum: A Propensity Score-Matched Analysis", AMERICAN JOURNAL OF NEPHROLOGY, 2022
dc.identifier.doi10.1159/000527180
dc.identifier.doihttps://www.webofscience.com/wos/woscc/full-record/WOS:000882633200001
dc.identifier.issn0250-8095
dc.identifier.urihttps://hdl.handle.net/11424/283508
dc.language.isoeng
dc.relation.ispartofAMERICAN JOURNAL OF NEPHROLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectNefroloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectNephrology
dc.subjectHealth Sciences
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectUROLOGY & NEPHROLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectÜroloji
dc.subjectUrology
dc.subjectAlport syndrome
dc.subjectCardiovascular outcomes
dc.subjectCollagen
dc.subjectGenetics
dc.subjectKidney transplantation
dc.subjectLiving donors
dc.subjectJOINT CONSENSUS RECOMMENDATION
dc.subjectRENAL-TRANSPLANT
dc.subjectMEDICAL GENETICS
dc.subjectAMERICAN-COLLEGE
dc.subjectGUIDELINES
dc.subjectSTANDARDS
dc.subjectVARIANTS
dc.subjectGENOTYPE
dc.subjectGENOMICS
dc.subjectRAMIPRIL
dc.titleLong-term outcomes of living-related kidney donation for alport syndrome spectrum: a propensity score-matched analysis
dc.typearticle
dspace.entity.typePublication
local.avesis.id2bcd882c-5e08-4a7b-a7cb-546ded2d73e3
local.indexed.atWOS
local.indexed.atPUBMED
relation.isAuthorOfPublicationa7410f0e-0eb4-4b83-ad61-a71dfbee164f
relation.isAuthorOfPublication.latestForDiscoverya7410f0e-0eb4-4b83-ad61-a71dfbee164f

Files

Collections

Research Outputs