Publication:
Evaluation of the Effect of Betahistine on Noise-Induced Hearing Loss Using Distortion Product Otoacoustic Emission and Scanning Electron Microscopy

Simple item page
dc.contributor.authorŞİRVANCI, SERAP
dc.contributor.authorsYilmaz, Hilmi; Aydin, Sedat; Sanli, Arif; Erdogan, Banu Atalay; Kibar, Sermin; Sirvanci, Serap; Kiran, Demir
dc.date.accessioned2022-03-14T11:01:22Z
dc.date.available2022-03-14T11:01:22Z
dc.date.issued2015-07-07
dc.description.abstractOBJECTIVE: To evaluate the protective effect of betahistine on noise-induced hearing loss (NIHL) using scanning electron microscopy (SEM) and distortion product otoacoustic emission (DPOAE). MATERIALS and METHODS: A total of 8 adult albino guinea pigs were used in this study (study group: n= 4 and control group: n= 4). DPOAE measurements of both groups were performed before the procedure. Two hours before noise exposure, 0.9% NaCl solution was injected perorally to the control group and betahistine was administered through a peroral catheter to the study group. Both groups were then exposed to 105-dB sound pressure level (SPL) 4-kHz frequency-based narrow-band noise for 2 h per day for 5 days. DPOAE measurements were performed again on the 6th day and cochleae were dissected and examined by SEM on the 7th day. RESULTS: Regarding the results of DPOAE, NIHL was observed in both groups on the 6th day (p< 0.05). Loss, flattening, and fusion, which are findings of permanent hearing loss, were determined in the stereocilia of the inner and outer hair cells by SEM. These findings were evaluated as signs of permanent increase in the threshold. When DPOAE measurements and SEM results were evaluated in the study group, no significant difference was observed in NIHL compared with the control group (p> 0.05). CONCLUSION: In our study, it was observed that simultaneous administration of betahistine during noise had no protective effect on permanent increase in the threshold. However, further studies on noise and long-term use of betahistine can be performed.
dc.identifier.doi10.5152/iao.2015.368
dc.identifier.issn1308-7649
dc.identifier.pubmed26223710
dc.identifier.urihttps://hdl.handle.net/11424/245741
dc.identifier.wosWOS:000357533000003
dc.language.isoeng
dc.publisherAVES
dc.relation.ispartofJOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBetahistine
dc.subjectnoise-induced hearing loss (NIHL)
dc.subjectscanning electron microscopy (SEM)
dc.subjectdistortion product otoacoustic emission (DPOAE)
dc.subjectACOUSTIC TRAUMA
dc.subjectGUINEA-PIG
dc.subjectSENSORY CELLS
dc.subjectINTENSE NOISE
dc.subjectHAIR-CELLS
dc.subjectINNER-EAR
dc.subjectEXPOSURE
dc.subjectRAT
dc.subjectAUDIOMETRY
dc.subjectCHANNELS
dc.titleEvaluation of the Effect of Betahistine on Noise-Induced Hearing Loss Using Distortion Product Otoacoustic Emission and Scanning Electron Microscopy
dc.typearticle
dspace.entity.typePublication
local.avesis.idfbb9710d-cd30-49a8-a771-628c4cfd740a
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages6
oaire.citation.endPage11
oaire.citation.issue1
oaire.citation.startPage6
oaire.citation.titleJOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
oaire.citation.volume11
relation.isAuthorOfPublicationfcdb4c83-6090-4b1e-8758-448d3b32b73a
relation.isAuthorOfPublication.latestForDiscoveryfcdb4c83-6090-4b1e-8758-448d3b32b73a

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
6-11.pdf
Size:
1.8 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs