Publication:
Bactericidal activity of the fluoroquinolone DU-6859a alone and in combination with other antimicrobial agents against multiresistant enterococci

Simple item page
dc.contributor.authorKORTEN, VOLKAN
dc.contributor.authorsKorten, V.; Erdem, I.; Murray, B. E.
dc.date.accessioned2022-03-15T11:13:25Z
dc.date.available2022-03-15T11:13:25Z
dc.date.issued1996
dc.description.abstractThe in vitro activity of DU-6859a (DU) alone and in combination with various antimicrobials was evaluated against multiresistant enterococci including some isolates with defined gyrA mutations. DU produced rapid in vitro killing against most enterococci that lacked resistance to ciprofloxacin, but it was not bactericidal against strains with MICs of ciprofloxacin of > or = 8 micrograms/ml, or against one of four strains with an MIC of ciprofloxacin of 4 micrograms/ml. The combination of DU with rifampin was antagonistic against two of two isolates tested. Combinations of DU and novobiocin, gentamicin, or a beta-lactam (amoxicillin, ampicillin-sulbactam, or amoxicillin-clavulanate) were generally indifferent. When different beta-lactams were used together, with or without DU, bactericidal activity was observed against some isolates. Despite the absence of synergistic interactions with other agents, DU is a promising fluoroquinolone for use against enterococci, although prior development of resistance to currently available fluoroquinolones diminishes some of its effect.
dc.identifier.doi10.1016/s0732-8893(96)00197-6
dc.identifier.issn0732-8893
dc.identifier.pubmedPMID: 8985660
dc.identifier.urihttps://hdl.handle.net/11424/249208
dc.language.isoeng
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDrug Combinations
dc.subjectAnti-Bacterial Agents
dc.subjectMicrobial Sensitivity Tests
dc.subjectGentamicins
dc.subjectDrug Synergism
dc.subjectAnti-Infective Agents
dc.subjectCiprofloxacin
dc.subjectDrug Resistance, Microbial
dc.subjectDrug Antagonism
dc.subjectGenetic Variation
dc.subjectAntibiotics, Antitubercular
dc.subjectRifampin
dc.subjectDNA Gyrase
dc.subjectDNA Topoisomerases, Type II
dc.subjectDrug Resistance, Multiple
dc.subjectEnterococcus
dc.subjectFluoroquinolones
dc.subjectLactams
dc.subjectNovobiocin
dc.subjectQuinolones
dc.titleBactericidal activity of the fluoroquinolone DU-6859a alone and in combination with other antimicrobial agents against multiresistant enterococci
dc.typearticle
dspace.entity.typePublication
local.avesis.id7822ecf7-7974-4c89-a5c1-12c8daea83bf
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage85
oaire.citation.startPage79
oaire.citation.titleDiagnostic Microbiology and Infectious Disease
oaire.citation.volume2
relation.isAuthorOfPublication27f6afa3-0e46-45c9-a302-a6493c69bffb
relation.isAuthorOfPublication.latestForDiscovery27f6afa3-0e46-45c9-a302-a6493c69bffb

Files

Collections

Research Outputs