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Investigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes

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dc.contributor.authorÖZBAŞ, SUNA
dc.contributor.authorsŞALVA E., ALAN S., Karakoyun B., Cakalagaoglu F., ÖZBAŞ S., Akbuga J.
dc.date.accessioned2023-07-31T10:16:28Z
dc.date.available2023-07-31T10:16:28Z
dc.date.issued2022-01-01
dc.description.abstractGranulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to promote the growth, proliferation, and migration of endothelial and keratinocyte cells. Chitosan has been widely used as a biopolymer in wound-healing studies. The aim of this study was to investigate the in vitro proliferative effects of chitosan/pGM-CSF complexes as well as the therapeutic role of the complexes in an in vivo rat wound model. The effect of complexes on cell proliferation and migration was examined. Wounds were made in Wistar-albino rats, and examined histopathologically. The cell proliferation and migration were increased weight ratio- and time-dependently in HaCaT and NIH-3T3 cell lines. Wound healing was significantly accelerated in rats treated with the complexes. These results showed that the delivery of pGM-CSF using chitosan complexes could play an accelerating role in the cell proliferation, migration, and wound-healing process.
dc.identifier.citationŞALVA E., ALAN S., Karakoyun B., Cakalagaoglu F., ÖZBAŞ S., Akbuga J., "Investigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes", BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.58, 2022
dc.identifier.doi10.1590/s2175-97902022e19668
dc.identifier.issn1984-8250
dc.identifier.urihttps://www.scielo.br/j/bjps/a/cXSQ45xWpr7yP95SHdSf56d/?format=pdf&lang=en
dc.identifier.urihttps://hdl.handle.net/11424/291858
dc.identifier.volume58
dc.language.isoeng
dc.relation.ispartofBRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectBasic Pharmaceutics Sciences
dc.subjectHealth Sciences
dc.subjectPharmacology and Therapeutics
dc.subjectLife Sciences
dc.subjectNatural Sciences
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectPHARMACOLOGY & PHARMACY
dc.subjectPHARMACOLOGY & TOXICOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectFarmakoloji
dc.subjectFarmakoloji, Toksikoloji ve Eczacılık (çeşitli)
dc.subjectGenel Farmakoloji, Toksikoloji ve Eczacılık
dc.subjectFarmakoloji (tıbbi)
dc.subjectİlaç Rehberleri
dc.subjectPharmacy
dc.subjectPharmacology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology (medical)
dc.subjectDrug Guides
dc.subjectWound healing
dc.subjectChitosan
dc.subjectpGM-CSF
dc.subjectComplexes
dc.subjectCOLONY-STIMULATING FACTOR
dc.subjectMOLECULAR-WEIGHT
dc.subjectGROWTH-FACTORS
dc.subjectGENE
dc.subjectNANOPARTICLES
dc.subjectDELIVERY
dc.subjectPROLIFERATION
dc.subjectPOLYPLEXES
dc.subjectEFFICIENCY
dc.subjectCYTOKINES
dc.subjectWound healing
dc.subjectChitosan
dc.subjectpGM-CSF
dc.subjectComplexes
dc.titleInvestigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes
dc.typearticle
dspace.entity.typePublication
local.avesis.id749a1d06-d779-49ea-a6ef-f8dcf0fa0b17
local.indexed.atWOS
local.indexed.atSCOPUS
relation.isAuthorOfPublicationd56d5fb1-37ec-4be6-8156-b58d67614019
relation.isAuthorOfPublication.latestForDiscoveryd56d5fb1-37ec-4be6-8156-b58d67614019

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