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Multi-Locus Candidate Gene Analyses of Lipid Levels in a Pediatric Turkish Cohort: Lessons Learned on LPL, CETP, LIPC, ABCA1, and SHBG

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dc.contributor.authorEREN, FATİH
dc.contributor.authorsAgirbasli, Mehmet; Eren, Fatih; Agirbasli, Deniz; White, Marquitta J.; Williams, Scott M.
dc.date.accessioned2022-03-14T10:55:12Z
dc.date.available2022-03-14T10:55:12Z
dc.date.issued2013-12
dc.description.abstractCardiovascular risk factors and atherosclerosis precursors were examined in 365 Turkish children and adolescents. Study participants were recruited at five different state schools. We tested single and multi-locus effects of six polymorphisms from five candidate genes, chosen based on prior known association with lipid levels in adults, for association with low (10(th) percentile) high density lipoprotein cholesterol (HDL-C) and high (90(th) percentile) triglycerides (TG), and the related continuous outcomes. We observed an association between CETP variant rs708272 and low HDL-C (allelic p=0.020, genotypic p=0.046), which was supported by an independent analysis, PRAT (PRAT control p=0.027). Sex-stratified logistic regression analysis showed that the B2 allele of rs708272 decreased odds of being in the lower tenth percentile of HDL-C measurements (OR=0.36, p=0.02) in girls; this direction of effect was also seen in boys but was not significant (OR=0.64, p=0.21). Logistic regression analysis also revealed that the T allele of rs6257 (SHBG) decreased odds of being in the top tenth percentile of TG measurements in boys (OR=0.43, p=0.03). Analysis of lipid levels as a continuous trait revealed a significant association between rs708272 (CETP) and LDL-C levels in males (p=0.02) with the B2B2 genotype group having the lowest mean LDL-C; the same direction of effect was also seen in females (p=0.05). An effect was also seen between rs708272 and HDL-C levels in girls (p=0.01), with the B2B2 genotype having the highest mean HDL-C levels. Multi-locus analysis, using quantitative multifactor dimensionality reduction (qMDR) identified the previously mentioned CETP variant as the best single locus model, and overall model, for predicting HDL-C levels in children. This study provides evidence for association between CETP and low HDL-C phenotype in children, but the results appear to be weaker in children than previous results in adults and may also be subject to gender effects.
dc.identifier.doi10.1089/omi.2013.0066
dc.identifier.eissn1557-8100
dc.identifier.issn1536-2310
dc.identifier.pubmed23988150
dc.identifier.urihttps://hdl.handle.net/11424/245464
dc.identifier.wosWOS:000329992000005
dc.language.isoeng
dc.publisherMARY ANN LIEBERT, INC
dc.relation.ispartofOMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHDL-CHOLESTEROL LEVELS
dc.subjectHORMONE-BINDING GLOBULIN
dc.subjectBODY-MASS INDEX
dc.subjectCARDIOVASCULAR RISK
dc.subjectTAQIB POLYMORPHISM
dc.subjectSEX-HORMONES
dc.subjectCHILDREN
dc.subjectASSOCIATION
dc.subjectBOGALUSA
dc.subjectATHEROSCLEROSIS
dc.titleMulti-Locus Candidate Gene Analyses of Lipid Levels in a Pediatric Turkish Cohort: Lessons Learned on LPL, CETP, LIPC, ABCA1, and SHBG
dc.typearticle
dspace.entity.typePublication
local.avesis.id79fd81d3-5375-462b-8aa7-caa6ce63d76c
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
oaire.citation.endPage645
oaire.citation.issue12
oaire.citation.startPage636
oaire.citation.titleOMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
oaire.citation.volume17
relation.isAuthorOfPublication4bc77d63-5aa7-4c67-8d60-12778ea963b1
relation.isAuthorOfPublication.latestForDiscovery4bc77d63-5aa7-4c67-8d60-12778ea963b1

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