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Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death

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dc.contributor.authorEREN, FATİH
dc.contributor.authorsImeryuz, Nese; Tahan, Veysel; Sonsuz, Abdullah; Eren, Fatih; Uraz, Suleyman; Yuksel, Meral; Akpulat, Sertac; Ozcelik, Dervis; Haklar, Goncagul; Celike, Cigdem; Avsar, Erol; Tozun, Nurdan
dc.date.accessioned2022-03-12T17:33:09Z
dc.date.available2022-03-12T17:33:09Z
dc.date.issued2007
dc.description.abstractBackground/Aims: High serum ferritin and liver iron concentrations were found in some patients with NASH, suggesting a role for iron as a co-factor that aggravates liver injury. The aim of this study is to investigate the effects of parenteral iron in a rat model of NASH induced by a methionine choline deficient diet (MCDD). Methods:Wistar rats were divided into 1 - Control, 2 - Iron (Fe), 3 - MCDD, 4 - MCDD&Fe groups. Iron dextran 100 mg/kg was administered intra-muscularly in groups 2 and 4. All rats were fed MCDD, Groups I and 2 were supplied with choline and methionine. Blood and tissue samples were obtained after 4 weeks. Results: The iron injection alone did not affect the liver whereas MCDD led to steatohepatitis. Iron worsened steatosis without any obvious effect on accompanying inflammation. It aggravated tissue injury by increasing apoptosis. Liver fibrosis was observed only in 3 out of 10 rats in the MCDD&Fe group. Conclusions: Observation of liver fibrosis only in the MCDD&Fe group suggests that iron induced increase in apoptosis contributes to the development of fibrosis at an earlier time than expected. (c) 2007 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.jhep.2007.06.018
dc.identifier.eissn1600-0641
dc.identifier.issn0168-8278
dc.identifier.pubmed17825453
dc.identifier.urihttps://hdl.handle.net/11424/228784
dc.identifier.wosWOS:000251491600015
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofJOURNAL OF HEPATOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectliver fibrosis
dc.subjectmethionine and choline deficient diet
dc.subjectnecroinflammation
dc.subjectreactive oxygen species
dc.subjectnonalcoholic steatohepatitis
dc.subjectMITOCHONDRIAL PERMEABILITY TRANSITION
dc.subjectNONALCOHOLIC STEATOHEPATITIS
dc.subjectHEPATIC IRON
dc.subjectFATTY LIVER
dc.subjectHEPATOCYTE APOPTOSIS
dc.subjectLIPID-PEROXIDATION
dc.subjectPROTEIN ADDUCTS
dc.subjectIN-VIVO
dc.subjectMODEL
dc.subjectFIBROSIS
dc.titleIron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death
dc.typearticle
dspace.entity.typePublication
local.avesis.idb184125e-6c29-449c-a260-a7773191d1bf
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage859
oaire.citation.issue6
oaire.citation.startPage851
oaire.citation.titleJOURNAL OF HEPATOLOGY
oaire.citation.volume47
relation.isAuthorOfPublication4bc77d63-5aa7-4c67-8d60-12778ea963b1
relation.isAuthorOfPublication.latestForDiscovery4bc77d63-5aa7-4c67-8d60-12778ea963b1

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