Publication:
Investigation of 3D-Printed Polycaprolactone-/Polyvinylpyrrolidone-Based Constructs

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsIzgordu, Muhammet Sefa; Uzgur, Evren Isa; Ulag, Songul; Sahin, Ali; Yilmaz, Betul Karademir; Kilic, Beyhan; Ekren, Nazmi; Oktar, Faik Nuzhet; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:42:54Z
dc.date.available2022-03-12T22:42:54Z
dc.description.abstractThe aim of this study is to evaluate the mechanical and biological performance of cartilage-like constructs produced by 3D printing. During the investigation, poly(epsilon-caprolactone) (PCL) and polyvinylpyrrolidone (PVP) were used as a matrix polymer and low-molecular-weight chitosan (CS), hyaluronic acid (HA), and alginic acid sodium salt (SA) were integrated separately with the polymer matrix to fabricate the constructs. Thermal, mechanical, morphology, and chemical properties and swelling, degradation, and biocompatibility behaviors were evaluated in detail. With the addition of 3 fillers, the melting temperature of the matrix increased with the addition of fillers, and PCL/3wt.%PVP/1wt.%HA had the highest melting temperature value. Mechanical characterization results demonstrated that the printed PCL/3wt.%PVP/1wt.%CS displayed the highest compressive strength of around 9.51 MPa. The compressive strength difference between the PCL/3wt.%PVP and PCL/3wt.%PVP/1wt.%CS was 5.38 MPa. Biocompatibility properties of the constructs were tested by mitochondrial dehydrogenase activity, and in vitro studies showed that the PCL/3wt.%PVP/1wt.%HA composite construct had more cell viability than the other constructs by making use of the mesenchymal stem cell line.
dc.identifier.doi10.1177/1947603519897302
dc.identifier.eissn1947-6043
dc.identifier.issn1947-6035
dc.identifier.pubmed31893944
dc.identifier.urihttps://hdl.handle.net/11424/236272
dc.identifier.wosWOS:000506786300001
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofCARTILAGE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcartilage tissue engineering
dc.subjectmesenchymal stem cell
dc.subjectpolycaprolactone
dc.subjectpolyvinylpyrrolidone
dc.subjectCARTILAGE REPAIR
dc.subjectHYALURONIC-ACID
dc.subjectSCAFFOLDS
dc.subjectCHITOSAN
dc.subjectBONE
dc.subjectDEGRADATION
dc.titleInvestigation of 3D-Printed Polycaprolactone-/Polyvinylpyrrolidone-Based Constructs
dc.typearticle
dspace.entity.typePublication
local.avesis.id901671a9-3fab-47a1-97ce-829289ce722a
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumber1947603519897300
local.journal.numberofpages10
local.journal.quartileQ1
oaire.citation.titleCARTILAGE
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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