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Serial MRI and MRS studies with unusual findings in Rasmussen's encephalitis

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dc.contributor.authorTÜRKDOĞAN, DİLŞAD
dc.contributor.authorsTurkdogan-Sozuer, D; Ozek, MM; Sav, A; Dincer, A; Pamir, MN
dc.date.accessioned2022-03-12T16:59:50Z
dc.date.available2022-03-12T16:59:50Z
dc.date.issued2000
dc.description.abstractRasmussen's syndrome is characterized by intractable seizures and progressive neuropsychiatric deterioration secondary to unilateral cortical inflammation and tissue destruction. Diagnosis of Rasmussen's syndrome in the early phase depends mainly on the clinical features. Neuroimaging and histopathologic examinations may not be specific during this period. We report a case of Rasmussen's syndrome followed by serial MRI and magnetic resonance spectroscopy (MRS) studies over a 3- to 16-month period. A healthy 6-year-old boy presented with focal motor seizures. An MRI study demonstrated prominent enlargement and T2 hyperintensity of the left mesial temporal lobe and perisylvian region. This early finding evolved to volume loss and later progressive atrophy of the ipsilateral hemisphere when epilepsia partialis continua occurred. Being aware of those early MRI features in a patient with increasing frequency of focal motor seizures should suggest Rasmussen's syndrome. In addition, we found prominently increased myoinositol concentration in atrophic cortex which might reflect increased gliosis in the late period of the disease.
dc.identifier.doi10.1007/s003300051045
dc.identifier.issn0938-7994
dc.identifier.pubmed10879711
dc.identifier.urihttps://hdl.handle.net/11424/227245
dc.identifier.wosWOS:000087540000018
dc.language.isoeng
dc.publisherSPRINGER VERLAG
dc.relation.ispartofEUROPEAN RADIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRasmussen's syndrome
dc.subjectneuroimaging early findings
dc.subjectmyoinositol
dc.subjectSTATUS EPILEPTICUS
dc.subjectBRAIN-TUMORS
dc.subjectSPECTROSCOPY
dc.titleSerial MRI and MRS studies with unusual findings in Rasmussen's encephalitis
dc.typearticle
dspace.entity.typePublication
local.avesis.id3673f50e-1923-4995-9a55-0a9d84bb2f06
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage966
oaire.citation.issue6
oaire.citation.startPage962
oaire.citation.titleEUROPEAN RADIOLOGY
oaire.citation.volume10
relation.isAuthorOfPublication0a1599c4-48ff-4aa9-b689-3927c986a650
relation.isAuthorOfPublication.latestForDiscovery0a1599c4-48ff-4aa9-b689-3927c986a650

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