Publication:
Increased CD4(+)CD16(+) and CD4(+)CD56(+) T cell subsets in Behcet's disease

Simple item page
dc.contributor.authorDİRESKENELİ, RAFİ HANER
dc.contributor.authorsEksioglu-Demiralp, E; Direskeneli, H; Ergun, T; Fresko, I; Akoglu, T
dc.date.accessioned2022-03-12T17:01:50Z
dc.date.available2022-03-12T17:01:50Z
dc.date.issued1999
dc.description.abstractBehcet's disease is a systemic vasculitis of unknown etiology. Various immune abnormalities have previously been shown in Behcet's disease. We investigated T lymphocyte subsets associated with cytotoxic activity and natural killer (NK) cells by flow cytometry in 37 patients with Behcet's disease, 38 healthy controls, and 17 diseased control patients. Compared to the healthy controls, CD4(+)CD16(+) and CD4(+)CD56(+) subsets were found to be higher in the Behcet's disease group as well as in the disease control group (CD4(+)CD16(+): B = 5 +/- 3, DC = 14 +/- 14, HC = 3 +/- 2, P = 0.001; CD4(+)CD56(+): ED = 11 +/- 5, DC = 18 +/- 17, HC = 8 +/- 6, P = 0.01). CD8(+)CD16(+) and CD8(+)CD56(+) T cell subsets were at normal levels in Behcet's disease but found to be elevated in disease controls. Similarly, NK cells (CD16(+)CD56(+)) were high only in the disease control group. Significant increases in CD4(+)CD16(+) and CD4(+)CD56(+) cell subsets in Behcet's patients and disease controls suggest that T cell activation patterns of these subsets in Behcet's disease are similar to those in other inflammatory disorders.
dc.identifier.doi10.1007/s002960050094
dc.identifier.issn0172-8172
dc.identifier.pubmed10651077
dc.identifier.urihttps://hdl.handle.net/11424/227418
dc.identifier.wosWOS:000084667300006
dc.language.isoeng
dc.publisherSPRINGER VERLAG
dc.relation.ispartofRHEUMATOLOGY INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBehcet's disease
dc.subjectcytotoxic T cells
dc.subjectCD16(+)CD56(+)
dc.subjectLYMPHOCYTES
dc.subjectPHENOTYPE
dc.subjectPROFILE
dc.subjectNUMBERS
dc.titleIncreased CD4(+)CD16(+) and CD4(+)CD56(+) T cell subsets in Behcet's disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id8e213054-4bd8-4c15-82b6-544b90055212
local.import.packageSS17
local.indexed.atWOS
local.journal.numberofpages4
oaire.citation.endPage26
oaire.citation.issue1-2
oaire.citation.startPage23
oaire.citation.titleRHEUMATOLOGY INTERNATIONAL
oaire.citation.volume19
relation.isAuthorOfPublication07a34d26-21f3-475d-bd36-152d6c659370
relation.isAuthorOfPublication.latestForDiscovery07a34d26-21f3-475d-bd36-152d6c659370

Files

Collections

Research Outputs