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Adhesive nanostructured multilayer films using a bacterial exopolysaccharide for biomedical applications

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dc.contributor.authorTOKSOY ÖNER, EBRU
dc.contributor.authorsCosta, Rui R.; Neto, Ana I.; Calgeris, Ilker; Correia, Clara R.; Pinho, Antonio C. M.; Fonseca, Jaime; Oner, Ebru T.; Mano, Joao F.
dc.date.accessioned2022-03-12T18:10:09Z
dc.date.available2022-03-12T18:10:09Z
dc.date.issued2013
dc.description.abstractMedical adhesives and sealants often require that long-term adhesiveness is achieved. In this work, nanostructured coatings consisting of chitosan and the adhesive bacterial exopolysaccharide levan are fabricated using layer-by-layer (LbL) assembly. Taking advantage of the electrostatic self-assembly mechanism of LbL, the charges of both chitosan and a phosphonate-derivatized levan (Ph-levan) are measured and the feasibility of constructing hybrid films is monitored and confirmed using a quartz crystal microbalance with dissipation monitoring (QCM-D). The adhesive properties between two identical bonded films with a total of 100 layers are compared to control films in which Ph-levan is replaced by alginate, revealing that the detachment force of the former is about 3 times higher than the control. Scanning electron microscopy of the films surface shows that the surface of Ph-levan films is smooth and homogeneous. Cell adhesion tests were conducted using a L929 cell line. Early cell adhesion is significantly higher in chitosan/Ph-levan films when compared to chitosan/alginate controls. These findings establish levan derivatives as bioinspired ingredients for conceiving medical adhesive devices that allow achieving enhanced mechanical and biological performance.
dc.identifier.doi10.1039/c3tb20137f
dc.identifier.eissn2050-7518
dc.identifier.issn2050-750X
dc.identifier.pubmed32261071
dc.identifier.urihttps://hdl.handle.net/11424/231357
dc.identifier.wosWOS:000317694700004
dc.language.isoeng
dc.publisherROYAL SOC CHEMISTRY
dc.relation.ispartofJOURNAL OF MATERIALS CHEMISTRY B
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPOLYMER-FILMS
dc.subjectCHITOSAN
dc.subjectALGINATE
dc.subjectCONTACT
dc.subjectSYSTEMS
dc.subjectMECHANICS
dc.subjectDELIVERY
dc.subjectORIGIN
dc.subjectTACK
dc.titleAdhesive nanostructured multilayer films using a bacterial exopolysaccharide for biomedical applications
dc.typearticle
dspace.entity.typePublication
local.avesis.id63002ddf-222f-4dd2-a2c8-99e26db9ec4f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage2374
oaire.citation.issue18
oaire.citation.startPage2367
oaire.citation.titleJOURNAL OF MATERIALS CHEMISTRY B
oaire.citation.volume1
relation.isAuthorOfPublication6118e9e4-a58e-429b-bbec-4f73a3089a2b
relation.isAuthorOfPublication.latestForDiscovery6118e9e4-a58e-429b-bbec-4f73a3089a2b

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